Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.2 uM | Antileishmanial activity against amastigote stage of Leishmania donovani infected in mouse J774A.1 cells assessed as parasite growth inhibition after 72 hrs by luciferase reporter gene assay | ChEMBL. | 23673014 |
Inhibition (functional) | = 72 % | Antileishmanial activity against amastigote stage of Leishmania donovani infected in golden hamster assessed as inhibition of parasite multiplication at 50 mg/kg, ip administered 5 days measured on day 7 by Giemsa staining assay relative to control | ChEMBL. | 23673014 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 23673014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.