Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0446 | 0.6166 | 0.6166 |
Echinococcus granulosus | pyruvate kinase | 0.0639 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0639 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0639 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0639 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0639 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0505 | 0.7331 | 0.5671 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0639 | 1 | 0.5 |
Leishmania major | pyruvate kinase | 0.0639 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0639 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0639 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0639 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0639 | 1 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0639 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0639 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0639 | 1 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0446 | 0.6166 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0639 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0639 | 1 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0639 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0639 | 1 | 1 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0193 | 0.1164 | 0.1164 |
Mycobacterium ulcerans | pyruvate kinase | 0.0639 | 1 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0639 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.6166 | 0.6166 |
Loa Loa (eye worm) | pyruvate kinase | 0.0639 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0639 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0639 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0639 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0639 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0639 | 1 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0639 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0639 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0639 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13.19 uM | Inhibition of androgen receptor in human LNCAP cells after 1 day by luciferase reporter gene assay | ChEMBL. | 23727044 |
IC50 (functional) | = 22.93 uM | Cytotoxicity against human LNCAP cells assessed as cell viability after 2 days by cell counting method | ChEMBL. | 23727044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.