Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.2755 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Giardia lamblia | Casein kinase II beta chain | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Brugia malayi | Csnk2b protein | 0.1501 | 0.4586 | 0.4586 |
Trypanosoma cruzi | casein kinase II, putative | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Entamoeba histolytica | casein kinase, putative | 0.2755 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.2755 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1501 | 0.4586 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.2755 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.2755 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1501 | 0.4586 | 0.4586 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.2755 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1501 | 0.4586 | 0.4586 |
Schistosoma mansoni | protein kinase | 0.2755 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.2755 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1501 | 0.4586 | 0.5 |
Loa Loa (eye worm) | Csnk2b protein | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.2755 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.2755 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1501 | 0.4586 | 0.4586 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.04 | Antagonist activity at recombinant human adenosine A2A receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production after 60 mins | ChEMBL. | 23602401 |
IC50 (binding) | = 9120 nM | Antagonist activity at recombinant human adenosine A2A receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production after 60 mins | ChEMBL. | 23602401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.