Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.2099 | 0.4657 | 0.4657 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.0811 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.4306 | 0.9997 | 1 |
Echinococcus multilocularis | MAM | 0.0509 | 0.0811 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.0811 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.2044 | 0.4523 | 0.4524 |
Loa Loa (eye worm) | TK protein kinase | 0.2099 | 0.4657 | 0.4658 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0188 | 0.0034 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.0811 | 0.0811 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0188 | 0.0034 | 0.0034 |
Echinococcus granulosus | MAM | 0.0509 | 0.0811 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.0811 | 0.0811 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.0811 | 1 |
Brugia malayi | hypothetical protein | 0.0509 | 0.0811 | 0.0811 |
Echinococcus multilocularis | tyrosine protein kinase | 0.2099 | 0.4657 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.2099 | 0.4657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3742 | 0.8631 | 0.8634 |
Onchocerca volvulus | 0.055 | 0.091 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/D50 (functional) | < 3.28 | Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. | ChEMBL. | 7069706 |
Log 1/LD10 (ADMET) | = 3.28 | Compound concentration in mole/kg/day lethal to 10% of mice | ChEMBL. | 7069706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.