Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase | 0.2865 | 0.6536 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.2865 | 0.6536 | 1 |
Onchocerca volvulus | 0.0562 | 0.0796 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.3683 | 0.8574 | 0.8577 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0252 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.0644 | 0.0644 |
Brugia malayi | hypothetical protein | 0.0501 | 0.0644 | 0.0644 |
Schistosoma mansoni | hypothetical protein | 0.0501 | 0.0644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.0644 | 0.0644 |
Echinococcus granulosus | MAM | 0.0501 | 0.0644 | 0.0986 |
Echinococcus multilocularis | MAM | 0.0501 | 0.0644 | 0.0986 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.2796 | 0.6363 | 0.6365 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0252 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | TK protein kinase | 0.2865 | 0.6536 | 0.6539 |
Brugia malayi | Protein kinase domain containing protein | 0.2865 | 0.6536 | 0.6536 |
Schistosoma mansoni | hypothetical protein | 0.0501 | 0.0644 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.4254 | 0.9996 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 960 nM | Displacement of [3H]-spiperone from human Dopamine receptor D4.4 expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 960 nM | Displacement of [3H]-spiperone from human Dopamine receptor D4.4 expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 31000 nM | Displacement of [3H]-spiperone from human Dopamine receptor D3 expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 31000 nM | Displacement of [3H]-spiperone from human Dopamine receptor D3 expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 49000 nM | Displacement of [3H]-spiperone from human Dopamine receptor D2L expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 49000 nM | Displacement of [3H]-spiperone from human Dopamine receptor D2L expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 61000 nM | Displacement of [3H]-SCH-23,390 from bovine striatal membrane Dopamine receptor D1 | ChEMBL. | 10560741 |
Ki (binding) | = 61000 nM | Displacement of [3H]-SCH-23,390 from bovine striatal membrane Dopamine receptor D1 | ChEMBL. | 10560741 |
Ki (binding) | = 65000 nM | Displacement of [3H]-spiperone from human Dopamine receptor D2S expressed in CHO cells | ChEMBL. | 10560741 |
Ki (binding) | = 65000 nM | Displacement of [3H]-spiperone from human Dopamine receptor D2S expressed in CHO cells | ChEMBL. | 10560741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.