Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | casein kinase, putative | 0.5039 | 1 | 1 |
Brugia malayi | casein kinase I | 0.5039 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.5039 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5039 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.5039 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.5039 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.5039 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.5039 | 1 | 1 |
Echinococcus granulosus | casein kinase I delta | 0.5039 | 1 | 0.5 |
Plasmodium falciparum | casein kinase 1 | 0.5039 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.5039 | 1 | 0.5 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.5039 | 1 | 0.5 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.5039 | 1 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.5039 | 1 | 0.5 |
Entamoeba histolytica | casein kinase 1, putative | 0.5039 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.5039 | 1 | 0.5 |
Leishmania major | casein kinase, putative | 0.5039 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.5039 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5039 | 1 | 1 |
Echinococcus multilocularis | casein kinase I alpha | 0.5039 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase i | 0.5039 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.5039 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.5039 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5039 | 1 | 1 |
Echinococcus granulosus | casein kinase I delta | 0.5039 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5039 | 1 | 1 |
Echinococcus multilocularis | casein kinase I delta | 0.5039 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.5039 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.5039 | 1 | 0.5 |
Plasmodium vivax | casein kinase 1, putative | 0.5039 | 1 | 0.5 |
Echinococcus granulosus | casein kinase i | 0.5039 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.5039 | 1 | 0.5 |
Onchocerca volvulus | 0.5039 | 1 | 1 | |
Echinococcus multilocularis | casein kinase I delta | 0.5039 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.5039 | 1 | 0.5 |
Toxoplasma gondii | casein kinase I | 0.5039 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 7.3 nM | Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incubated for 15 mins prior to NECA/forskolin challenge measured after 5.5 to 6 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 23522563 |
Ki (functional) | < 16 nM | Antagonist activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as inhibition of R-PIA/forskolin-induced cAMP accumulation incubated for 15 mins prior to R-PIA/forskolin challenge measured after 5.5 to 6 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 23522563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.