Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Telomerase reverse transcriptase | 0.3067 | 0.7215 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0235 | 0.037 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0235 | 0.037 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1153 | 0.2588 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0235 | 0.037 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1153 | 0.2588 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1153 | 0.2588 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1153 | 0.2588 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0235 | 0.037 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0235 | 0.037 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1153 | 0.2588 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1153 | 0.2588 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0235 | 0.037 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1153 | 0.2588 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1153 | 0.2588 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.