Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0154 | 0.1975 | 0.4171 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0154 | 0.1975 | 0.4171 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0162 | 0.2383 | 0.5033 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0176 | 0.3025 | 0.6389 |
Mycobacterium ulcerans | glutaminase | 0.032 | 1 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0211 | 0.4734 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0144 | 0.1506 | 0.3182 |
Echinococcus granulosus | glutamate receptor 2 | 0.0127 | 0.0673 | 0.1422 |
Schistosoma mansoni | glutaminase | 0.032 | 1 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0176 | 0.3025 | 0.6389 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0162 | 0.2383 | 0.5033 |
Trichomonas vaginalis | glutaminase, putative | 0.032 | 1 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0194 | 0.3901 | 0.824 |
Loa Loa (eye worm) | glutaminase | 0.032 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0162 | 0.2383 | 0.5033 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0211 | 0.4734 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.032 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0127 | 0.0673 | 0.1422 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0194 | 0.3901 | 0.824 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0289 | 0.8521 | 0.8157 |
Echinococcus granulosus | glutamate receptor 2 | 0.0162 | 0.2383 | 0.5033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 42 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/mL after 12 to 28 days by Lowenstein-Jensen method relative to control | ChEMBL. | 23567957 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | ChEMBL. | 23567957 |
MIC (functional) | = 1000 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | ChEMBL. | 23567957 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.