Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1925 | 0.594 | 0.594 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1476 | 0.4133 | 0.4133 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1476 | 0.4133 | 0.4133 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.2933 | 1 | 1 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.2484 | 0.8192 | 0.8192 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1925 | 0.594 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0449 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.2484 | 0.8192 | 0.8192 |
Entamoeba histolytica | hypothetical protein | 0.0449 | 0 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1476 | 0.4133 | 0.4133 |
Entamoeba histolytica | hypothetical protein | 0.0449 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.2933 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1476 | 0.4133 | 0.4133 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2933 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1925 | 0.594 | 0.594 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0449 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2933 | 1 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1476 | 0.4133 | 0.6957 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antibacterial activity against Escherichia coli CCM 4517 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | ChEMBL. | 23659859 | |
GI (functional) | Antifungal activity against Candida albicans ATCC 44859 assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | ChEMBL. | 23659859 | |
MIC (functional) | = 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 14 days by microdilution method | ChEMBL. | 23659859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.