Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | casein kinase I | 0.5317 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I delta | 0.5317 | 1 | 0.5 |
Echinococcus granulosus | casein kinase i | 0.5317 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I delta | 0.5317 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I delta | 0.5317 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5317 | 1 | 1 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.5317 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5317 | 1 | 1 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.5317 | 1 | 1 |
Echinococcus multilocularis | casein kinase i | 0.5317 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.5317 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.5317 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5317 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5317 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.5317 | 1 | 1 |
Plasmodium falciparum | casein kinase 1 | 0.5317 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.5317 | 1 | 0.5 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.5317 | 1 | 0.5 |
Toxoplasma gondii | casein kinase I | 0.5317 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.5317 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.5317 | 1 | 0.5 |
Entamoeba histolytica | casein kinase 1, putative | 0.5317 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.5317 | 1 | 0.5 |
Leishmania major | casein kinase, putative | 0.5317 | 1 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.5317 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.5317 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.5317 | 1 | 1 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.5317 | 1 | 0.5 |
Plasmodium vivax | casein kinase 1, putative | 0.5317 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I delta | 0.5317 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.5317 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.5317 | 1 | 0.5 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.5317 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.5317 | 1 | 0.5 |
Onchocerca volvulus | 0.5317 | 1 | 1 | |
Trichomonas vaginalis | CK1 family protein kinase | 0.5317 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.25 uM | Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay | ChEMBL. | 23750455 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23750455 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.