Detailed information for compound 1764673

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.353 | Formula: C15H13FN4O2S
  • H donors: 1 H acceptors: 4 LogP: 1.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nnn(c1)Cc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C15H13FN4O2S/c16-13-5-3-12(4-6-13)15-10-20(19-18-15)9-11-1-7-14(8-2-11)23(17,21)22/h1-8,10H,9H2,(H2,17,21,22)
  • InChiKey: KYHFEXDYGOYACU-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase shark 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus SH2 motif 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1359 0.3309 0.3309
Schistosoma mansoni hypothetical protein 0.1359 0.3309 0.3309
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.2268 1 1
Schistosoma mansoni tensin-related 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2268 1 1
Leishmania major protein kinase, putative 0.0909 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.1359 0.3309 0.3309
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1359 0.3309 0.3309
Schistosoma mansoni shc transforming protein 0.1359 0.3309 0.3309
Echinococcus granulosus signal transduction protein lnk realted 0.1359 0.3309 0.3309
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Fyn 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus c src tyrosine kinase 0.2268 1 1
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2268 1 1
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Leishmania major protein kinase, putative 0.0909 0 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.1359 0.3309 0.3309
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2268 1 1
Onchocerca volvulus 0.1359 0.3309 0.3309
Schistosoma mansoni growth factor receptor-bound protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.2268 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0909 0 0.5
Leishmania major hypothetical protein, conserved 0.0909 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Onchocerca volvulus 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein kinase shark 0.2268 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0909 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.1359 0.3309 0.3309
Giardia lamblia Kinase, NEK 0.0909 0 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2268 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Plasmodium vivax protein kinase, putative 0.0909 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0909 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2268 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0909 0 0.5
Schistosoma mansoni tyrosine kinase 0.2268 1 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0909 0 0.5
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Onchocerca volvulus 0.2268 1 1
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Trypanosoma cruzi protein kinase, putative 0.0909 0 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni tensin-related 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0909 0 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni tyrosine kinase 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1359 0.3309 0.3309
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine kinase 0.2268 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Onchocerca volvulus 0.1359 0.3309 0.3309
Brugia malayi Protein kinase domain containing protein 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1359 0.3309 0.3309
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Fyn 0.2268 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.2268 1 1
Echinococcus multilocularis NCK adaptor protein 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Src42A 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine kinase 0.2268 1 1
Brugia malayi SH2 domain containing protein 0.2268 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0909 0 0.5
Schistosoma mansoni SH2A 0.1359 0.3309 0.3309
Schistosoma mansoni tensin 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2268 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.1359 0.3309 0.3309
Entamoeba histolytica SH2 domain containing protein 0.1359 0.3309 0.3309
Toxoplasma gondii protein kinase domain-containing protein 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.2268 1 1
Echinococcus granulosus tyrosine kinase 0.2268 1 1
Echinococcus multilocularis c src tyrosine kinase 0.2268 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1359 0.3309 0.3309
Echinococcus multilocularis SH2 motif 0.1359 0.3309 0.3309
Schistosoma mansoni tensin 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Schistosoma mansoni nck2/grb4 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Onchocerca volvulus 0.1359 0.3309 0.3309
Brugia malayi hypothetical protein 0.2268 1 1
Brugia malayi Tensin 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis SH2 motif 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein kinase Blk 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus SH2 motif 0.1359 0.3309 0.3309
Onchocerca volvulus 0.1359 0.3309 0.3309
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0909 0 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0909 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0909 0 0.5
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.1359 0.3309 0.3309
Onchocerca volvulus 0.1359 0.3309 0.3309
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1359 0.3309 0.3309
Onchocerca volvulus 0.2268 1 1
Loa Loa (eye worm) STAT protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Echinococcus granulosus expressed conserved protein 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni GTPase activating protein 0.1359 0.3309 0.3309
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Brugia malayi Protein kinase domain containing protein 0.2268 1 1
Brugia malayi protein-tyrosine kinase 0.2268 1 1
Schistosoma mansoni adapter molecule crk 0.1359 0.3309 0.3309
Trichomonas vaginalis TK family protein kinase 0.0909 0 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis tensin 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Giardia lamblia Kinase, NEK 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Blk 0.2268 1 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.1359 0.3309 0.3309
Entamoeba histolytica protein kinase, putative 0.1359 0.3309 0.3309
Schistosoma mansoni tyrosine kinase 0.2268 1 1
Brugia malayi Variant SH3 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.1359 0.3309 0.3309
Onchocerca volvulus 0.2268 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0909 0 0.5
Plasmodium falciparum protein kinase, putative 0.0909 0 0.5
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Onchocerca volvulus 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0909 0 0.5
Echinococcus granulosus suppressor of cytokine signaling 7 0.1359 0.3309 0.3309
Toxoplasma gondii protein kinase 0.0909 0 0.5
Onchocerca volvulus 0.2268 1 1
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2268 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2268 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2268 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2268 1 1
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis STE family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Giardia lamblia Kinase 0.0909 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Brugia malayi Sex muscle abnormal protein 5 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Plasmodium falciparum protein kinase, putative 0.0909 0 0.5
Giardia lamblia Protein 21.1 0.0909 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Echinococcus granulosus SH2 domain containing protein 7 0.1359 0.3309 0.3309
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Brugia malayi Protein kinase domain containing protein 0.2268 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0909 0 0.5
Schistosoma mansoni tyrosine kinase 0.2268 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1359 0.3309 0.3309
Echinococcus granulosus growth factor receptor bound protein 2 0.1359 0.3309 0.3309
Echinococcus multilocularis N chimaerin 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Echinococcus granulosus N chimaerin 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2268 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Echinococcus granulosus NCK adaptor protein 0.1359 0.3309 0.3309
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1359 0.3309 0.3309
Loa Loa (eye worm) SH2 domain-containing protein 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Lyn 0.2268 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.1359 0.3309 0.3309
Brugia malayi Variant SH3 domain containing protein 0.1359 0.3309 0.3309
Brugia malayi Protein kinase domain containing protein 0.2268 1 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0909 0 0.5
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1359 0.3309 0.3309
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1359 0.3309 0.3309
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus hypothetical protein 0.1359 0.3309 0.3309
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2268 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1359 0.3309 0.3309
Trypanosoma brucei protein kinase, putative 0.0909 0 0.5
Brugia malayi RhoGAP domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus tensin 0.1359 0.3309 0.3309
Trypanosoma brucei Pseudokinase, putative 0.0909 0 0.5
Echinococcus multilocularis SHC transforming protein 3 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.2268 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1359 0.3309 0.3309
Schistosoma mansoni tyrosine kinase 0.2268 1 1
Schistosoma mansoni tyrosine kinase 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0909 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Src42A 0.2268 1 1
Plasmodium falciparum protein kinase, putative 0.0909 0 0.5
Echinococcus multilocularis SH2 motif 0.1359 0.3309 0.3309
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2268 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1359 0.3309 0.3309
Trichomonas vaginalis conserved hypothetical protein 0.0909 0 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1359 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2268 1 1
Echinococcus granulosus SHC transforming protein 3 0.1359 0.3309 0.3309
Trypanosoma cruzi protein kinase, putative 0.0909 0 0.5
Brugia malayi SH2 domain containing protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.1359 0.3309 0.3309
Loa Loa (eye worm) TK protein kinase 0.2268 1 1
Echinococcus multilocularis tensin 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) hypothetical protein 0.2268 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2268 1 1
Toxoplasma gondii STE kinase 0.0909 0 0.5
Schistosoma mansoni hypothetical protein 0.1359 0.3309 0.3309
Schistosoma mansoni growth factor receptor-bound protein 0.1359 0.3309 0.3309
Onchocerca volvulus 0.2268 1 1
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Brugia malayi hypothetical protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Brugia malayi SH2 domain containing protein 0.2268 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.1359 0.3309 0.3309
Trichomonas vaginalis AGC family protein kinase 0.0909 0 0.5
Echinococcus granulosus SH2 domain containing adapter protein F 0.1359 0.3309 0.3309
Brugia malayi tRNA modification GTPase TrmE family protein 0.1359 0.3309 0.3309
Loa Loa (eye worm) SRC-1 0.2268 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2268 1 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1359 0.3309 0.3309
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2268 1 1
Schistosoma mansoni vav2 0.1359 0.3309 0.3309
Brugia malayi SRC-1 0.2268 1 1
Schistosoma mansoni tensin 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0909 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0909 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1359 0.3309 0.3309

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 uM Inhibition of human recombinant COX2 by fluorescence assay ChEMBL. 23706267
IC50 (binding) = 20 uM Inhibition of ovine COX1 by fluorescence assay ChEMBL. 23706267

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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