Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.1287 | 0.5 | 0.5 |
Schistosoma mansoni | enhancer of zeste ezh | 0.1287 | 0.5 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.1287 | 0.5 | 0.5 |
Loa Loa (eye worm) | SET domain-containing protein | 0.1287 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant PDGFR-beta expressed in insect cells using Ulight-Poly GAT[EAY(1:1:1)] as substrate at 1 uM after 15 to 60 mins by fluorescence assay | ChEMBL. | 23562241 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.