Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.356 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 1 | 1 |
Schistosoma mansoni | amidase | 0.0123 | 1 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.356 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 1 | 1 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.356 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.356 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.356 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.356 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.356 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.356 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.356 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.356 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.356 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.356 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.356 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0063 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.356 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.356 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.088 uM | Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
IC50 (binding) | = 0.22 uM | Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.