Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2641 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.2641 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0187 | 0.0101 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0093 | 0.2953 | 0.7327 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2641 | 0.5 |
Echinococcus granulosus | MAM | 0.0016 | 0.0187 | 0.0068 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.2641 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0187 | 0.0101 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.2641 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0187 | 0.0101 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2641 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.2641 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0016 | 0.0187 | 0.0101 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0161 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.2641 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2641 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.403 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2641 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2641 | 1 |
Schistosoma mansoni | amidase | 0.0123 | 0.403 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2641 | 1 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0161 | 0.0033 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0161 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0148 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.403 | 1 |
Brugia malayi | amidase | 0.0123 | 0.403 | 0.3941 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.403 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0161 | 0.0399 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.403 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0187 | 0.0465 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.2641 | 1 |
Brugia malayi | putative amidase | 0.0015 | 0.0161 | 0.0013 |
Onchocerca volvulus | 0.0085 | 0.2679 | 0.9025 | |
Brugia malayi | Amidase family protein | 0.0015 | 0.0161 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2953 | 0.7225 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.403 | 1 |
Brugia malayi | Trypsin family protein | 0.0093 | 0.2953 | 0.2847 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0187 | 0.004 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0161 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2641 | 0.5 |
Onchocerca volvulus | 0.0093 | 0.2953 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.402 | 0.9973 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2641 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0.2641 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2641 | 0.5 |
Onchocerca volvulus | 0.0016 | 0.0187 | 0.014 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0187 | 0.0465 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.2641 | 1 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0161 | 0.0033 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0015 | 0.0161 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2953 | 0.7225 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2641 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0016 | 0.0187 | 0.004 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2641 | 1 |
Echinococcus multilocularis | MAM | 0.0016 | 0.0187 | 0.0068 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2641 | 0.5 |
Brugia malayi | Amidase family protein | 0.0015 | 0.0161 | 0.0013 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.2641 | 1 |
Onchocerca volvulus | 0.0016 | 0.0187 | 0.014 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0098 | 0.3144 | 0.78 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2641 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.012 uM | Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
IC50 (binding) | = 0.023 uM | Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.