Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.1299 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.3159 | 0.2359 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0464 | 0.3159 | 0.2359 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.1299 | 1 | 0.5 |
Onchocerca volvulus | 0.1299 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0078 | 0 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.1299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.3159 | 0.2359 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0464 | 0.3159 | 0.2359 |
Brugia malayi | Kringle domain containing protein | 0.1299 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.1299 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.1299 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1299 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1299 | 1 | 1 |
Onchocerca volvulus | 0.0258 | 0.1476 | 0.0479 | |
Toxoplasma gondii | kringle domain-containing protein | 0.1299 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0464 | 0.3159 | 0.2359 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.1299 | 1 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1299 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.0464 | 0.3159 | 0.2359 | |
Mycobacterium ulcerans | hypothetical protein | 0.0206 | 0.1046 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.59 uM | Antileishmanial activity against promastigotes of Leishmania donovani MHOM/IN/60/Dd8 after 72 hrs by luciferase reporter gene assay | ChEMBL. | 23611626 |
IC50 (functional) | > 40 uM | Antileishmanial activity against amastigotes of Leishmania donovani MHOM/IN/60/Dd8 infected in mouse J-774A.1 cells after 72 hrs by luciferase reporter gene assay | ChEMBL. | 23611626 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 23611626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.