Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate dehydrogenase | 0.0115 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2926 | 0.2 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0115 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2926 | 0.2 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2926 | 0.2 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0115 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0115 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0109 | 0.9145 | 0.8791 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0115 | 1 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0115 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2926 | 0.2 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2926 | 0.2 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2926 | 0.2 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0115 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0047 | 0.0855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0109 | 0.9145 | 0.8791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.