Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.5389 | 0.506 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.0665 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0125 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.0665 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.5389 | 0.506 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0125 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.5389 | 0.506 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.0665 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.0665 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.5389 | 0.5389 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.0665 | 0.0665 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0125 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.0665 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0125 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.5389 | 0.506 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.5389 | 0.506 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.5389 | 0.506 |
Brugia malayi | Isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.5389 | 0.506 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.0665 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.0665 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.0665 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0665 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0125 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.5389 | 0.506 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0665 | 0.5 |
Brugia malayi | glutathione reductase | 0.0076 | 0.5389 | 0.5389 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0125 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0125 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0125 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.5389 | 0.506 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0125 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0125 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.5389 | 0.506 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.0665 | 0.5 |
Leishmania major | trypanothione reductase | 0.0076 | 0.5389 | 0.506 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.48 ug ml-1 | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
ED50 (functional) | = 1.48 ug ml-1 | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
ED50 (functional) | = 2.55 uM | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
ED50 (functional) | = 2.55 uM | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
IC50 (binding) | = 10 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
IC50 (binding) | = 10 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Ki (binding) | = 1.67 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Ki (binding) | = 1.67 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.