TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.488 | Formula: C21H20N6O2S
H donors: 2 H acceptors: 4 LogP: 1.44 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1csc(n1)N1Cc2c(C1=O)cccc2)Nc1cnccc1N1CCNCC1
InChi: 1S/C21H20N6O2S/c28-19(24-16-11-23-6-5-18(16)26-9-7-22-8-10-26)17-13-30-21(25-17)27-12-14-3-1-2-4-15(14)20(27)29/h1-6,11,13,22H,7-10,12H2,(H,24,28)
InChiKey: AGTFRKAFDLLYOF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	checkpoint kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130454	All targets in OG5_130454
Schistosoma japonicum	Serine/threonine-protein kinase Chk1, putative	Get druggable targets OG5_130454	All targets in OG5_130454

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0383	0.3368	0.3373
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0637	0.9985	1
Echinococcus granulosus	NCK adaptor protein	0.0383	0.3368	0.3368
Schistosoma mansoni	suppressor of cytokine signaling	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	activin receptor type	0.0254	0.0015	0.0015
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0637	0.9985	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0383	0.3368	0.3373
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0383	0.3368	0.3373
Schistosoma mansoni	vav2	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Giardia lamblia	Protein 21.1	0.0254	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0383	0.3368	0.3373
Giardia lamblia	Kinase, NEK	0.0254	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tensin	0.0383	0.3368	0.3368
Echinococcus granulosus	hypothetical protein	0.0383	0.3368	0.3368
Loa Loa (eye worm)	TK/ABL protein kinase	0.0637	0.9985	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0637	0.9985	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0383	0.3368	0.3368
Echinococcus granulosus	SH2 motif	0.0383	0.3368	0.3368
Brugia malayi	SH2 domain containing protein	0.0637	0.9985	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Brugia malayi	protein-tyrosine kinase	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	N chimaerin	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine kinase	0.0637	0.9985	0.9985
Echinococcus granulosus	c src tyrosine kinase	0.0637	0.9985	0.9985
Echinococcus multilocularis	c src tyrosine kinase	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0383	0.3368	0.3373
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0637	0.9985	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0383	0.3368	0.3368
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0254	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0383	0.3368	0.3373
Brugia malayi	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0637	0.9985	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	SH2 motif	0.0383	0.3368	0.3373
Brugia malayi	RhoGAP domain containing protein	0.0383	0.3368	0.3373
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0383	0.3368	0.3373
Schistosoma mansoni	GTPase activating protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Schistosoma mansoni	hypothetical protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0637	0.9985	1
Echinococcus multilocularis	tensin	0.0383	0.3368	0.3373
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0383	0.3368	0.3373
Schistosoma mansoni	tensin-related	0.0383	0.3368	0.3373
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Onchocerca volvulus		0.0383	0.3368	0.3373
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0637	0.9985	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0637	0.9985	1
Schistosoma mansoni	tensin-related	0.0383	0.3368	0.3373
Schistosoma mansoni	shc transforming protein	0.0383	0.3368	0.3373
Schistosoma mansoni	tyrosine kinase	0.0637	0.9985	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Echinococcus granulosus	SH2 motif	0.0383	0.3368	0.3368
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0254	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0383	0.3368	0.3373
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0637	0.9985	0.9985
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Echinococcus granulosus	N chimaerin	0.0383	0.3368	0.3368
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0637	0.9985	0.9985
Echinococcus granulosus	tyrosine kinase	0.0637	0.9985	0.9985
Loa Loa (eye worm)	SRC-1	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Schistosoma mansoni	protein kinase	0.0254	0.0015	0.0015
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0383	0.3368	0.3368
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0637	0.9985	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0637	0.9985	1
Schistosoma mansoni	SH2A	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0254	0.0015	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Echinococcus multilocularis	NCK adaptor protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0383	0.3368	0.3373
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0383	0.3368	0.3373
Onchocerca volvulus		0.0383	0.3368	0.3373
Onchocerca volvulus		0.0383	0.3368	0.3373
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0254	0.0015	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0384	0.3382	0.3387
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0637	0.9985	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0637	0.9985	0.9985
Schistosoma mansoni	growth factor receptor-bound protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0254	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Echinococcus multilocularis	SH2 motif	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Onchocerca volvulus		0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0637	0.9985	1
Schistosoma mansoni	adapter molecule crk	0.0383	0.3368	0.3373
Schistosoma mansoni	protein kinase	0.0254	0.0015	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0637	0.9985	0.9985
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0383	0.3368	0.3368
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0383	0.3368	0.3368
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0637	0.9985	0.9985
Brugia malayi	SRC-1	0.0637	0.9985	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Trypanosoma brucei	protein kinase, putative	0.0254	0.0015	1
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0637	0.9985	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0637	0.9985	1
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Schistosoma mansoni	growth factor receptor-bound protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Loa Loa (eye worm)	hypothetical protein	0.0637	0.9985	1
Schistosoma mansoni	tensin	0.0383	0.3368	0.3373
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0637	0.9985	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0383	0.3368	0.3373
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0254	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	expressed conserved protein	0.0383	0.3368	0.3368
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Schistosoma mansoni	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0254	0.0015	0.0015
Loa Loa (eye worm)	SH2 domain-containing protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0637	0.9985	0.9985
Giardia lamblia	Kinase, NEK	0.0254	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine protein kinase shark	0.0637	0.9985	0.9985
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Onchocerca volvulus		0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0637	0.9985	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0383	0.3368	0.3373
Giardia lamblia	Kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	activin receptor type	0.0254	0.0015	0.0015
Brugia malayi	Tensin	0.0383	0.3368	0.3373
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0384	0.3382	0.3387
Plasmodium falciparum	protein kinase, putative	0.0254	0.0015	1
Onchocerca volvulus		0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0637	0.9985	0.9985
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0637	0.9985	1
Schistosoma mansoni	tensin	0.0383	0.3368	0.3373
Schistosoma mansoni	suppressor of cytokine signaling	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Leishmania major	protein kinase, putative	0.0254	0.0015	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Onchocerca volvulus		0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Onchocerca volvulus		0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0637	0.9985	0.9985
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0383	0.3368	0.3373
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0383	0.3368	0.3373
Schistosoma mansoni	signal transduction protein lnk-related	0.0383	0.3368	0.3373
Echinococcus multilocularis	SH2 motif	0.0383	0.3368	0.3373
Brugia malayi	Protein kinase domain containing protein	0.0637	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	tyrosine protein kinase shark	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0254	0	0.5
Schistosoma mansoni	nck2/grb4	0.0383	0.3368	0.3373
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis		0.0383	0.3368	0.3373
Echinococcus granulosus	growth factor receptor bound protein 2	0.0383	0.3368	0.3368
Brugia malayi	Variant SH3 domain containing protein	0.0383	0.3368	0.3373
Schistosoma mansoni	tensin	0.0383	0.3368	0.3373
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Brugia malayi	hypothetical protein	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Onchocerca volvulus		0.0383	0.3368	0.3373
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0637	0.9985	0.9985
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	SHC transforming protein 3	0.0383	0.3368	0.3373
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0637	0.9985	0.9985
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0383	0.3368	0.3373
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Loa Loa (eye worm)	STAT protein	0.0383	0.3368	0.3373
Echinococcus multilocularis	tensin	0.0383	0.3368	0.3373
Trichomonas vaginalis	TK family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0383	0.3368	0.3373
Brugia malayi	SH2 domain containing protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0637	0.9985	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0254	0	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0254	0.0015	0.0015
Schistosoma mansoni	tyrosine kinase	0.0637	0.9985	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0637	0.9985	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0383	0.3368	0.3373
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0254	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0254	0.0015	0.0015
Trichomonas vaginalis	STE family protein kinase	0.0254	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0383	0.3368	0.3373
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0383	0.3368	0.3373
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0254	0.0015	1
Onchocerca volvulus		0.0637	0.9985	1
Schistosoma mansoni	tyrosine kinase	0.0637	0.9985	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0637	0.9985	0.9985
Brugia malayi	SH2 domain containing protein	0.0637	0.9985	1
Brugia malayi	Protein kinase domain containing protein	0.0637	0.9985	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0637	0.9985	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0254	0.0015	1
Schistosoma mansoni	protein kinase	0.0254	0.0015	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0637	0.9985	1
Plasmodium vivax	protein kinase, putative	0.0254	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0637	0.9985	0.9985
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0383	0.3368	0.3368
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0383	0.3368	0.3373
Onchocerca volvulus		0.0637	0.9985	1
Schistosoma mansoni	tyrosine kinase	0.0637	0.9985	1
Onchocerca volvulus		0.0637	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0254	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 100 nM	Inhibition of CHK1 in human U2OS cells assessed as phosphorylation of H2AX after 2 hrs by FITC/propidium iodide staining-based immunofluorescence assay in presence of hydroxyurea	ChEMBL.	23535330
IC50 (binding)	= 2 nM	Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate after 2 hrs by scintillation proximity assay in presence of [gamma33P]-ATP	ChEMBL.	23535330

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2381115

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1766465