Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Onchocerca volvulus | Get druggable targets OG5_132502 | All targets in OG5_132502 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin B | 0.0165 | 0.0646 | 0.0641 |
Echinococcus multilocularis | cyclin b3 | 0.0079 | 0.02 | 0.0194 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0165 | 0.0646 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0165 | 0.0646 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0165 | 0.0646 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0165 | 0.0646 | 1 |
Echinococcus granulosus | cyclins | 0.0079 | 0.02 | 0.0194 |
Trichomonas vaginalis | cyclin B3, putative | 0.0079 | 0.02 | 0.3026 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.02 | 0.3026 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0165 | 0.0646 | 1 |
Echinococcus granulosus | calcium release activated calcium channel | 0.1984 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Echinococcus granulosus | cyclins | 0.0079 | 0.02 | 0.0194 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0182 | 0.0734 | 0.0728 |
Trichomonas vaginalis | cyclin B, putative | 0.0165 | 0.0646 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0182 | 0.0734 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0723 | 0.0723 |
Trichomonas vaginalis | cyclins, putative | 0.0165 | 0.0646 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0165 | 0.0646 | 0.0641 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.1984 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0079 | 0.02 | 0.0194 |
Trichomonas vaginalis | cyclins, putative | 0.0079 | 0.02 | 0.3026 |
Leishmania major | cyclin | 0.0165 | 0.0646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0699 | 0.0699 |
Trypanosoma cruzi | cyclin, putative | 0.0165 | 0.0646 | 1 |
Schistosoma mansoni | cyclin B | 0.0165 | 0.0646 | 0.0641 |
Giardia lamblia | Hypothetical protein | 0.0079 | 0.02 | 0.3026 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0182 | 0.0734 | 0.0734 |
Trichomonas vaginalis | cyclins, putative | 0.0165 | 0.0646 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0165 | 0.0646 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0165 | 0.0646 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0041 | 0.0006 | 0.0006 |
Trichomonas vaginalis | cyclins, putative | 0.0165 | 0.0646 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.0079 | 0.02 | 0.0194 |
Echinococcus granulosus | cyclin B3 1 | 0.0079 | 0.02 | 0.0194 |
Toxoplasma gondii | hypothetical protein | 0.006 | 0.0102 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0652 | 0.0652 |
Schistosoma mansoni | cyclins | 0.0079 | 0.02 | 0.0194 |
Plasmodium vivax | protein kinase Crk2 | 0.0041 | 0.0006 | 0.5 |
Giardia lamblia | Cyclin A | 0.0079 | 0.02 | 0.3026 |
Entamoeba histolytica | cyclin family protein | 0.0079 | 0.02 | 0.3026 |
Trichomonas vaginalis | cyclins, putative | 0.0165 | 0.0646 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0165 | 0.0646 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0106 | 0.034 | 0.5209 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.02 | 0.3026 |
Trichomonas vaginalis | cyclin B, putative | 0.0079 | 0.02 | 0.3026 |
Schistosoma mansoni | Protein orai-1 | 0.1984 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0652 | 0.0652 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0041 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0167 | 0.0652 | 1 | |
Trichomonas vaginalis | cyclin B, putative | 0.0165 | 0.0646 | 1 |
Plasmodium falciparum | cyclin | 0.0079 | 0.02 | 1 |
Echinococcus granulosus | cyclins | 0.0079 | 0.02 | 0.0194 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0165 | 0.0646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0242 | 0.0242 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.1984 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0165 | 0.0646 | 0.0641 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0182 | 0.0734 | 0.0728 |
Entamoeba histolytica | cyclin family protein | 0.0079 | 0.02 | 0.3026 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0041 | 0.0006 | 0.0006 |
Schistosoma mansoni | cyclin B3 | 0.0182 | 0.0734 | 0.0728 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Trypanosoma cruzi | cyclin 6, putative | 0.0165 | 0.0646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0646 | 0.0646 |
Schistosoma mansoni | Protein orai-1 | 0.1984 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0079 | 0.02 | 0.0194 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.02 | 0.0194 |
Echinococcus granulosus | cyclin B | 0.0165 | 0.0646 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0652 | 0.0652 |
Echinococcus granulosus | cyclin b3 | 0.0079 | 0.02 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0079 | 0.02 | 0.3026 |
Entamoeba histolytica | cyclin, putative | 0.0079 | 0.02 | 0.3026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | < 4 | Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 23582444 |
Ki (binding) | = 690 nM | Inhibition of [3H]PDBu binding to PKCdelta-C1B domain peptide (unknown origin) | ChEMBL. | 23582444 |
Ki (binding) | = 8700 nM | Inhibition of [3H]PDBu binding to PKCdelta-C1A domain peptide (unknown origin) | ChEMBL. | 23582444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.