Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0719 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0403 | 0.5126 | 0.5126 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0719 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0719 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0719 | 1 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0719 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0161 | 0.1404 | 0.1404 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0719 | 1 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0161 | 0.1404 | 0.1404 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0719 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0719 | 1 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0403 | 0.5126 | 0.5126 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0161 | 0.1404 | 0.1404 |
Plasmodium vivax | RNA helicase-1, putative | 0.0719 | 1 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0719 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0719 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0719 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0719 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1404 | 0.1404 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0719 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0161 | 0.1404 | 0.1404 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0719 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0719 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0719 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0719 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1404 | 0.1404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 56 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition at 6.25 ug/ml after 5 to 8 days by microplate alamar blue assay relative to control | ChEMBL. | 23876988 |
MIC (functional) | < 6.25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 8 days by microplate alamar blue assay | ChEMBL. | 23876988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.