TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 567.698 | Formula: C33H33N3O4S
H donors: 1 H acceptors: 2 LogP: 5.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccc(c2c1c1ccccc1s2)c1cccc2c1oc(cc2=O)N1CCOCC1)CN1CCCCCC1
InChi: 1S/C33H33N3O4S/c37-27-20-30(36-16-18-39-19-17-36)40-32-22(9-7-10-24(27)32)23-12-13-26(31-25-8-3-4-11-28(25)41-33(23)31)34-29(38)21-35-14-5-1-2-6-15-35/h3-4,7-13,20H,1-2,5-6,14-19,21H2,(H,34,38)
InChiKey: REVMVJOOBVUMAH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	putative neuropeptide receptor NPR1	0.0032	0.0601	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0032	0.0601	0.0339
Loa Loa (eye worm)	TYRA-2 protein	0.0032	0.0601	1
Brugia malayi	GnHR receptor homolog	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0032	0.0601	0.0339
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0032	0.0601	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0032	0.0601	0.0339
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Brugia malayi	sulfakinin receptor protein	0.0032	0.0601	1
Echinococcus multilocularis	fmrfamide receptor	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0601	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0601	0.0339
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0601	0.0339
Brugia malayi	neuropeptide F receptor	0.0032	0.0601	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0032	0.0601	0.0339
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0601	0.0339
Brugia malayi	Melatonin receptor type 1A	0.0032	0.0601	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0271	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0032	0.0601	0.0339
Echinococcus granulosus	hypothetical protein	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Brugia malayi	Dopamine receptor protein 1	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	amine GPCR	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0601	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0032	0.0601	1
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0601	1
Echinococcus granulosus	sex peptide receptor	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0032	0.0601	0.5
Onchocerca volvulus		0.0032	0.0601	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0601	0.0339
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Echinococcus granulosus	7TM GPCR rhodopsin	0.0032	0.0601	0.0339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Brugia malayi	ORL1-like opioid receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Brugia malayi	G-protein coupled receptor	0.0032	0.0601	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0032	0.0601	0.0339
Brugia malayi	RE15519p	0.0032	0.0601	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0032	0.0601	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0032	0.0601	0.0339
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0601	0.0339
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0601	0.0339
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	hypothetical protein	0.0032	0.0601	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0601	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Schistosoma mansoni	amine GPCR	0.0032	0.0601	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Schistosoma mansoni	amine GPCR	0.0032	0.0601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Brugia malayi	Serotonin receptor	0.0032	0.0601	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0271	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0601	0.0339
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0032	0.0601	1
Giardia lamblia	GTOR	0.0022	0.0271	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	histamine h1 receptor	0.0032	0.0601	1
Echinococcus multilocularis	neuropeptide s receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	neuropeptide s receptor	0.0032	0.0601	0.0339
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.32	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0601	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0601	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0601	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0032	0.0601	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	g-protein coupled receptor	0.0032	0.0601	0.0339
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Brugia malayi	Dopamine receptor protein 2	0.0032	0.0601	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0601	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0271	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0601	1
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0601	0.0339
Echinococcus multilocularis	G protein coupled receptor 139	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0032	0.0601	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0032	0.0601	0.0339
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0601	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Brugia malayi	putative neuropeptide receptor	0.0032	0.0601	1
Echinococcus multilocularis	g-protein coupled receptor	0.0032	0.0601	0.0339
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0032	0.0601	0.0339
Echinococcus granulosus	dro:myosuppressin receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0032	0.0601	1
Brugia malayi	AKH receptor	0.0032	0.0601	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0271	0.5
Brugia malayi	Dopamine receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0271	0.4507
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Brugia malayi	G-protein coupled receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	serotonin receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	serotonin receptor	0.0032	0.0601	0.0339
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0032	0.0601	0.0339
Schistosoma mansoni	opsin-like receptor	0.0032	0.0601	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0032	0.0601	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0032	0.0601	0.0339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Brugia malayi	follicle stimulating hormone receptor	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	fmrfamide receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	amine GPCR	0.0032	0.0601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	amine GPCR	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	myosin xvIII	0.0032	0.0601	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	opsin-like receptor	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0032	0.0601	1
Echinococcus granulosus	somatostatin receptor	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	neuropeptide receptor A26	0.0032	0.0601	0.0339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Leishmania major	hypothetical protein, conserved	0.0114	0.334	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0032	0.0601	1
Echinococcus multilocularis	sex peptide receptor	0.0032	0.0601	0.0339
Brugia malayi	Serotonin receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0032	0.0601	0.0339
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus multilocularis	somatostatin receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0032	0.0601	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0032	0.0601	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0601	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0032	0.0601	0.0339
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0032	0.0601	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Schistosoma mansoni	opsin-like receptor	0.0032	0.0601	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0601	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0601	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0032	0.0601	1
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0032	0.0601	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0032	0.0601	1
Echinococcus multilocularis	serotonin receptor	0.0032	0.0601	0.0339
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0032	0.0601	0.0339
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0271	0.4507
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0032	0.0601	0.0339
Onchocerca volvulus		0.0032	0.0601	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0601	0.0339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0032	0.0601	1
Echinococcus multilocularis	orexin receptor type 2	0.0032	0.0601	0.0339
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0032	0.0601	0.5
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0032	0.0601	0.5
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0271	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0601	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0032	0.0601	0.0339
Echinococcus granulosus	orexin receptor type 2	0.0032	0.0601	0.0339
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0271	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0601	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0032	0.0601	0.0339
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0601	0.0339
Echinococcus granulosus	allatostatin A receptor	0.0032	0.0601	0.0339
Echinococcus multilocularis	neuropeptides capa receptor	0.0032	0.0601	0.0339
Echinococcus multilocularis	allatostatin A receptor	0.0032	0.0601	0.0339
Brugia malayi	larval opioid receptor	0.0032	0.0601	1
Echinococcus granulosus	G protein coupled receptor 139	0.0032	0.0601	0.0339
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0032	0.0601	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0032	0.0601	0.0339
Echinococcus multilocularis	fmrfamide receptor	0.0032	0.0601	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0032	0.0601	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0601	0.0339
Brugia malayi	G protein-coupled receptor	0.0032	0.0601	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0601	0.0339
Schistosoma mansoni	hypothetical protein	0.0032	0.0601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0601	0.0339
Brugia malayi	neuropeptide F receptor	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Schistosoma mansoni	adenoreceptor	0.0032	0.0601	1
Brugia malayi	hypothetical protein	0.0032	0.0601	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0032	0.0601	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	1
Onchocerca volvulus		0.0032	0.0601	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 51 nM	Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assay	ChEMBL.	23855836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2420431

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1768221