Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | pyruvate kinase | 0.011 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.011 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.011 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.011 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.011 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.011 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.011 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.011 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.011 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.011 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.011 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.011 | 1 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0077 | 0.5661 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.011 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.011 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.011 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.011 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.011 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.011 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.011 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.011 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.011 | 1 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.011 | 1 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.011 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.011 | 1 | 0.5 |
Leishmania major | pyruvate kinase | 0.011 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.011 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0087 | 0.6979 | 0.5671 |
Echinococcus granulosus | pyruvate kinase | 0.011 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 uM | Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured every 30 seconds for 10 mins by fluorescence microplate reader analysis | ChEMBL. | 23844670 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.