Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 63.2 mg kg-1 | Acute toxicity in ip dosed mouse | ChEMBL. | 23811259 |
MIC (functional) | > 500 ug ml-1 | Antifungal activity against Candida albicans 885-653 measured every 24 hrs for 14 days by conventional dilution method | ChEMBL. | 23811259 |
MIC (functional) | > 500 ug ml-1 | Antibacterial activity against Escherichia coli F-50 measured every 24 hrs for 5 days by conventional dilution method | ChEMBL. | 23811259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.