Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0016 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0016 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0048 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0391 | 0.0841 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0016 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0016 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0016 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.443 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0016 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.443 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0391 | 0.0841 | 1 |
Toxoplasma gondii | hypothetical protein | 0.443 | 1 | 0.5 |
Onchocerca volvulus | 0.0057 | 0.0083 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.443 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0016 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0016 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0083 | 0.0083 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0016 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0016 | 0.0016 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0083 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0016 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0016 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0048 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0016 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0016 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0016 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0016 | 0.0016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | In vivo tumor-promoting activity in DMBA-treated ICR mouse assessed as tumor bearing mouse at 3.4 nmol administered twice per week measured after 20 weeks by two-stage carcinogenesis assay relative to control | ChEMBL. | 23803585 | |
GI50 (functional) | = 5.43 | Growth inhibition of human PC3 cells after 48 hrs by SRB assay | ChEMBL. | 23803585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.