Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0143 | 0.0269 | 0.0269 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0647 | 0.3838 | 0.3838 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1519 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0647 | 0.3838 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0647 | 0.3838 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0143 | 0.0269 | 0.0269 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0143 | 0.0269 | 0.0269 |
Entamoeba histolytica | casein kinase, putative | 0.0647 | 0.3838 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0647 | 0.3838 | 0.3838 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Schistosoma mansoni | protein kinase | 0.0647 | 0.3838 | 0.3838 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0647 | 0.3838 | 0.3838 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0143 | 0.0269 | 0.0269 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1519 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0647 | 0.3838 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0143 | 0.0269 | 0.0269 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0647 | 0.3838 | 0.5 |
Mycobacterium leprae | Possible transporter protein | 0.0105 | 0 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1519 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0143 | 0.0269 | 0.0269 |
Brugia malayi | Casein kinase II, alpha chain | 0.0647 | 0.3838 | 0.3838 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0143 | 0.0269 | 0.0269 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1519 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0647 | 0.3838 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0647 | 0.3838 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0647 | 0.3838 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1519 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.1056 | 0.673 | 0.673 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1519 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1519 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0647 | 0.3838 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0647 | 0.3838 | 1 |
Plasmodium vivax | unspecified product | 0.0647 | 0.3838 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of TCPTP (unknown origin) | ChEMBL. | 23942421 | |
IC50 (binding) | = 17.94 uM | Inhibition of SHP1 (unknown origin) | ChEMBL. | 23942421 |
IC50 (binding) | = 21.45 uM | Inhibition of SHP2 (unknown origin) | ChEMBL. | 23942421 |
IC50 (binding) | = 78.19 uM | Inhibition of PTP1B (unknown origin) | ChEMBL. | 23942421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.