TDR Targets

Basic information

Technical information

TDR Targets ID: 1769176
Name: (2S,3S,4R)-4-(4-methoxyphenyl)-3-methyl-6-nit ro-2-phenyl-1,2,3,4-tetrahydroquinoline
MW: 374.432 | Formula: C23H22N2O3
H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)[C@@H]1c2cc(ccc2N[C@@H]([C@H]1C)c1ccccc1)[N+](=O)[O-]
InChi: 1S/C23H22N2O3/c1-15-22(16-8-11-19(28-2)12-9-16)20-14-18(25(26)27)10-13-21(20)24-23(15)17-6-4-3-5-7-17/h3-15,22-24H,1-2H3/t15-,22+,23-/m0/s1
InChiKey: IMXQHIQNAKWAOL-BJQRDSPESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	protein-tyrosine kinase	0.0773	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0463	0.4474	0.4474
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Schistosoma mansoni	tensin-related	0.0463	0.4474	0.3308
Plasmodium vivax	tyrosine kinase-like protein, putative	0.031	0.1742	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0463	0.4474	0.3308
Echinococcus granulosus	signal transduction protein lnk realted	0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0463	0.4474	0.4474
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Entamoeba histolytica	protein kinase, putative	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Echinococcus multilocularis	SH2 motif	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Brugia malayi	Immunoglobulin I-set domain containing protein	0.031	0.1742	0.1436
Schistosoma mansoni	nck2/grb4	0.0463	0.4474	0.3308
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.031	0.1742	0.5
Toxoplasma gondii	protein kinase	0.031	0.1742	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.4474	0.4269
Giardia lamblia	Kinase, NEK	0.031	0.1742	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0463	0.4474	0.4269
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0773	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.031	0.1742	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0463	0.4474	0.3308
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.031	0.1742	0.1436
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0463	0.4474	0.3308
Onchocerca volvulus		0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Brugia malayi	Guanylyl cyclase protein 23	0.031	0.1742	0.1436
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.031	0.1742	0.1436
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0773	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Schistosoma mansoni	GTPase activating protein	0.0463	0.4474	0.3308
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0773	1	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.031	0.1742	0.1742
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.031	0.1742	0.1742
Brugia malayi	SH2 domain containing protein	0.0773	1	1
Brugia malayi	Raf kinase	0.031	0.1742	0.1436
Brugia malayi	Protein kinase domain containing protein	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.023218	0.106769	0.5
Trypanosoma cruzi	protein kinase, putative	0.031	0.1742	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0463	0.4474	0.4474
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.031	0.1742	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0773	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.031	0.1742	0.1742
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	RGC/RGC protein kinase	0.031	0.1742	0.1742
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Onchocerca volvulus		0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.031	0.1742	0.5
Trypanosoma brucei	protein kinase, putative	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0773	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Leishmania major	protein kinase, putative	0.031	0.1742	0.5
Schistosoma mansoni	adapter molecule crk	0.0463	0.4474	0.3308
Trichomonas vaginalis	TK family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Onchocerca volvulus		0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0463	0.4474	0.4269
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.0773	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.031	0.1742	0.1742
Echinococcus granulosus	SH2 domain containing protein 7	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0463	0.4474	0.3308
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.031	0.1742	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0773	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Echinococcus granulosus	NCK adaptor protein	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0232	0.0358	0.0358
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	N chimaerin	0.0463	0.4474	0.3308
Brugia malayi	hypothetical protein	0.031	0.1742	0.1436
Brugia malayi	Receptor family ligand binding region containing protein	0.031	0.1742	0.1436
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	RGC/RGC protein kinase	0.031	0.1742	0.1742
Schistosoma mansoni	hypothetical protein	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.0773	1	1
Echinococcus multilocularis		0.0463	0.4474	0.3308
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	SH2 motif	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	hypothetical protein	0.04	0.335	0.335
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0463	0.4474	0.3308
Echinococcus granulosus	hypothetical protein	0.0463	0.4474	0.3308
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus granulosus	SH2 motif	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Plasmodium falciparum	protein kinase, putative	0.031	0.1742	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0463	0.4474	0.4474
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.031	0.1742	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Onchocerca volvulus		0.0773	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Brugia malayi	hypothetical protein	0.031	0.1742	0.1436
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.4474	0.4269
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.031	0.1742	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0773	1	1
Giardia lamblia	Kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.031	0.1742	0.1436
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0773	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0463	0.4474	0.3308
Echinococcus multilocularis	tensin	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0773	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.031	0.1742	0.1742
Echinococcus granulosus	tyrosine kinase	0.0773	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0773	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Leishmania major	protein kinase, putative	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	hypothetical protein	0.0463	0.4474	0.4269
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.4474	0.4269
Schistosoma mansoni	tyrosine kinase	0.0773	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Brugia malayi	Furin-like cysteine rich region family protein	0.031	0.1742	0.1436
Onchocerca volvulus		0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Leishmania major	hypothetical protein, conserved	0.031	0.1742	0.5
Trichomonas vaginalis	AGC family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Loa Loa (eye worm)	TK/ABL protein kinase	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.0399925	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Entamoeba histolytica	SH2 domain containing protein	0.0463	0.4474	0.3308
Trichomonas vaginalis	STE family protein kinase	0.031	0.1742	0.5
Onchocerca volvulus		0.0463	0.4474	0.3308
Loa Loa (eye worm)	SH2 domain-containing protein	0.0463	0.4474	0.4474
Echinococcus granulosus	expressed conserved protein	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK/Met protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Brugia malayi	Protein kinase domain containing protein	0.0773	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.031	0.1742	0.5
Echinococcus granulosus	N chimaerin	0.0463	0.4474	0.3308
Brugia malayi	Tyrosine-protein kinase PR2	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK/DDR protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.023218	0.106769	0.106769
Schistosoma mansoni	tyrosine kinase	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.4474	0.4269
Giardia lamblia	Protein 21.1	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.031	0.1742	0.1742
Onchocerca volvulus		0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	SH2 domain-containing protein	0.0463	0.4474	0.4474
Schistosoma mansoni	tensin	0.0463	0.4474	0.3308
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Brugia malayi	ephrin receptor 1 precursor	0.031	0.1742	0.1436
Brugia malayi	Immunoglobulin I-set domain containing protein	0.031	0.1742	0.1436
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	tyrosine kinase	0.0773	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Plasmodium falciparum	protein kinase, putative	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.031	0.1742	0.1436
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0773	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0773	1	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.031	0.1742	0.1742
Trypanosoma brucei	Pseudokinase, putative	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0463	0.4474	0.3308
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.031	0.1742	0.1436
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	STAT protein	0.0463	0.4474	0.4474
Onchocerca volvulus		0.0773	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0463	0.4474	0.3308
Echinococcus granulosus	tyrosine kinase	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.0773	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK/INSR protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0463	0.4474	0.3308
Onchocerca volvulus		0.0773	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0773	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0463	0.4474	0.4474
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Schistosoma mansoni	tyrosine kinase	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Schistosoma mansoni	signal transduction protein lnk-related	0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0463	0.4474	0.4474
Echinococcus multilocularis	NCK adaptor protein	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	tensin-related	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Echinococcus multilocularis	SHC transforming protein 3	0.0463	0.4474	0.3308
Plasmodium falciparum	tyrosine kinase-like protein	0.031	0.1742	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0463	0.4474	0.3308
Onchocerca volvulus		0.0773	1	1
Plasmodium vivax	protein kinase, putative	0.031	0.1742	0.5
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Brugia malayi	integrin-linked kinase	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK protein kinase	0.0773	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0773	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.031	0.1742	0.1742
Echinococcus multilocularis	tyrosine kinase	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Echinococcus granulosus	tensin	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK/ROR protein kinase	0.031	0.1742	0.1742
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	SH2 domain containing protein	0.0773	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0463	0.4474	0.4474
Plasmodium falciparum	tyrosine kinase-like protein	0.031	0.1742	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.031	0.1742	0.5
Brugia malayi	RhoGAP domain containing protein	0.0463	0.4474	0.4269
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0463	0.4474	0.4269
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Toxoplasma gondii	STE kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Giardia lamblia	Kinase, NEK	0.031	0.1742	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Echinococcus multilocularis	signal transduction protein lnk realted	0.0463	0.4474	0.3308
Schistosoma mansoni	tyrosine kinase	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0463	0.4474	0.3308
Loa Loa (eye worm)	SRC-1	0.0773	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.031	0.1742	0.5
Schistosoma mansoni	SH2A	0.0463	0.4474	0.3308
Echinococcus granulosus	growth factor receptor bound protein 2	0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Echinococcus granulosus	tyrosine protein kinase shark	0.0773	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.031	0.1742	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.031	0.1742	0.1436
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Schistosoma mansoni	vav2	0.0463	0.4474	0.3308
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	hypothetical protein	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.031	0.1742	0.5
Echinococcus granulosus	SH2 motif	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	tensin	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0773	1	1
Schistosoma mansoni	tensin	0.0463	0.4474	0.3308
Echinococcus multilocularis	c src tyrosine kinase	0.0773	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0463	0.4474	0.4269
Schistosoma mansoni	growth factor receptor-bound protein	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Toxoplasma gondii	protein kinase domain-containing protein	0.031	0.1742	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0463	0.4474	0.3308
Brugia malayi	Tensin	0.0463	0.4474	0.4269
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0463	0.4474	0.3308
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0463	0.4474	0.3308
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0773	1	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0463	0.4474	0.3308
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0773	1	1
Trypanosoma cruzi	protein kinase, putative	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0463	0.4474	0.3308
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Echinococcus granulosus	tyrosine protein kinase Srms	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.031	0.1742	0.1742
Onchocerca volvulus		0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.1742	0.5
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0463	0.4474	0.3308
Onchocerca volvulus		0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Schistosoma mansoni	shc transforming protein	0.0463	0.4474	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0463	0.4474	0.4474
Brugia malayi	C-terminal src kinase protein 1	0.031	0.1742	0.1436
Plasmodium vivax	tyrosine kinase-like protein, putative	0.031	0.1742	0.5
Brugia malayi	Protein kinase domain containing protein	0.031	0.1742	0.1436
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Plasmodium falciparum	protein kinase, putative	0.031	0.1742	0.5
Brugia malayi	SH2 domain containing protein	0.0463	0.4474	0.4269
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0463	0.4474	0.3308
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0463	0.4474	0.4269
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0773	1	1
Brugia malayi	hypothetical protein	0.0773	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.1742	0.1742
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.031	0.1742	0.1742
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0773	1	1
Echinococcus multilocularis	tensin	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK protein kinase	0.031	0.1742	0.1742
Brugia malayi	SRC-1	0.0773	1	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.1742	0.5
Echinococcus multilocularis	SH2 motif	0.0463	0.4474	0.3308
Loa Loa (eye worm)	TK/FER protein kinase	0.0773	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0463	0.4474	0.3308
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0773	1	1
Schistosoma mansoni	tyrosine kinase	0.0773	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 76.03 %	Antiparasitic activity against epimastigotes of Trypanosoma cruzi CL Brener expressing Escherichia coli lacZ gene infected in mouse NCTC-929 cells assessed as parasite growth inhibition at 32 uM after 72 hrs by colorimetric assay	ChEMBL.	23899616
IC50 (functional)	< 8 uM	Antiparasitic activity against epimastigotes of Trypanosoma cruzi CL Brener expressing Escherichia coli lacZ gene infected in mouse NCTC-929 cells assessed as parasite growth inhibition after 72 hrs by colorimetric assay	ChEMBL.	23899616

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma cruzi	ChEMBL23	23899616

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2419735

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1769176