Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosyl-DNA phosphodiesterase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | traf and tnf receptor associated protein | Get druggable targets OG5_131766 | All targets in OG5_131766 |
Neospora caninum | endonuclease/exonuclease/phosphatase domain- containing protein, putative | Get druggable targets OG5_131766 | All targets in OG5_131766 |
Echinococcus granulosus | traf and tnf receptor associated protein | Get druggable targets OG5_131766 | All targets in OG5_131766 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | Get druggable targets OG5_131766 | All targets in OG5_131766 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | Get druggable targets OG5_131766 | All targets in OG5_131766 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | Get druggable targets OG5_131766 | All targets in OG5_131766 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | KREX1 | tyrosyl-DNA phosphodiesterase 2 | 362 aa | 321 aa | 20.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0593 | 0.5 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0593 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0593 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0593 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0593 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0593 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0593 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0593 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0593 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0593 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0593 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0593 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0593 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0593 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0593 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0593 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0593 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0593 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0593 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0593 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0593 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0593 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 4.66 uM | Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 mins | ChEMBL. | 23859074 |
IC50 (binding) | > 200 uM | Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assay | ChEMBL. | 23859074 |
Imax (binding) | = 75 % | Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 mins | ChEMBL. | 23859074 |
Inhibition (binding) | < 30 % | Inhibition of TDP1 (unknown origin) using double-stranded AP-site containing DNA as substrate at 100 uM after 30 mins by fluorescence assay relative to control | ChEMBL. | 23859074 |
permeability (ADMET) | = 0.41 ucm/s | Permeability across apical to basolateral side in human Caco2 cells | ChEMBL. | 23859074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.