Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 20 uM | Antiparasitic activity against Trypanosoma brucei brucei BF427 assessed as growth inhibition by Alamar Blue assay | ChEMBL. | 24354316 |
IC50 (functional) | > 10 uM | Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream form after 48 hrs by Alamar blue assay | ChEMBL. | 23831695 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 23831695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.