Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.1867 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0664 | 0.9322 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0198 | 0.2783 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0712 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0198 | 0.2783 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0198 | 0.0198 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0199 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1065 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0198 | 0.1861 |
Onchocerca volvulus | 0.0163 | 0.3504 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0664 | 0.6233 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0198 | 0.2783 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1065 | 0.1065 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0198 | 0.2783 |
Brugia malayi | hypothetical protein | 0.004 | 0.0712 | 0.6686 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0199 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.00000000027722 | 0.00000000027722 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0712 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0198 | 0.0198 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.2792 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0712 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0198 | 0.2783 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0712 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0198 | 0.1861 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0198 | 0.2783 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.2792 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0712 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0198 | 0.2783 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0199 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0199 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.0199 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0198 | 0.2783 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.2792 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0199 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1065 | 0.1065 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.1867 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0198 | 0.2783 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0199 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.2792 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0198 | 0.2783 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.2792 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0199 | 0.2792 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0712 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0712 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0199 | 0.2792 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0199 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0712 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.091 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream form after 70 hrs by Alamar blue assay | ChEMBL. | 23831695 |
IC50 (functional) | = 0.26 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes infected in rat L6 cells after 96 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 23831695 |
IC50 (functional) | = 0.3 uM | Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream form after 48 hrs by Alamar blue assay | ChEMBL. | 23831695 |
IC50 (functional) | = 4.9 uM | Antimicrobial activity against Plasmodium falciparum NF54 infected in human RBC after 48 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 23831695 |
IC50 (functional) | = 12 uM | Antimicrobial activity against Leishmania donovani amastigote form infected in mouse peritoneal macrophage after 96 hrs by Giemsa staining method | ChEMBL. | 23831695 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 23831695 | |
Plasmodium falciparum | ChEMBL23 | 23831695 | |
Trypanosoma brucei gambiense | 23831695 | ||
Trypanosoma cruzi | ChEMBL23 | 23831695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.