Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.145255 | 0.446445 | 0.446445 |
Brugia malayi | Hemopexin family protein | 0.00386974 | 0.0105962 | 0.0237346 |
Brugia malayi | Matrixin family protein | 0.00272918 | 0.00708023 | 0.0158591 |
Mycobacterium ulcerans | thymidylate synthase | 0.0523006 | 0.159894 | 1 |
Onchocerca volvulus | 0.00272918 | 0.00708023 | 0.0442808 | |
Schistosoma mansoni | tyrosine kinase | 0.00683991 | 0.0197524 | 0.0442437 |
Loa Loa (eye worm) | hypothetical protein | 0.00272918 | 0.00708023 | 0.0158591 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.00332401 | 0.00891389 | 0.0199664 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.145255 | 0.446445 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.324824 | 1 | 1 |
Onchocerca volvulus | 0.0523006 | 0.159894 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.145255 | 0.446445 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523006 | 0.159894 | 0.5 |
Brugia malayi | hypothetical protein | 0.0248809 | 0.0753672 | 0.168816 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.145255 | 0.446445 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0523006 | 0.159894 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.00992293 | 0.0292563 | 0.0292563 |
Loa Loa (eye worm) | matrixin family protein | 0.00605319 | 0.0173271 | 0.0388113 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.00272918 | 0.00708023 | 0.0158591 |
Loa Loa (eye worm) | hypothetical protein | 0.145255 | 0.446445 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.00605319 | 0.0173271 | 0.108366 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523006 | 0.159894 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.145255 | 0.446445 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0523006 | 0.159894 | 0.358149 |
Brugia malayi | Matrixin family protein | 0.00659892 | 0.0190095 | 0.0425796 |
Schistosoma mansoni | hypothetical protein | 0.145255 | 0.446445 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523006 | 0.159894 | 0.358149 |
Echinococcus multilocularis | thymidylate synthase | 0.0523006 | 0.159894 | 0.159894 |
Brugia malayi | thymidylate synthase | 0.0523006 | 0.159894 | 0.358149 |
Loa Loa (eye worm) | hypothetical protein | 0.00332401 | 0.00891389 | 0.0199664 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.00696311 | 0.0201322 | 0.0201322 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0523006 | 0.159894 | 1 |
Brugia malayi | Matrixin family protein | 0.00272918 | 0.00708023 | 0.0158591 |
Loa Loa (eye worm) | hypothetical protein | 0.00272918 | 0.00708023 | 0.0158591 |
Echinococcus granulosus | thymidylate synthase | 0.0523006 | 0.159894 | 0.159894 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0523006 | 0.159894 | 1 |
Brugia malayi | Matrixin family protein | 0.00272918 | 0.00708023 | 0.0158591 |
Onchocerca volvulus | Matrilysin homolog | 0.00272918 | 0.00708023 | 0.0442808 |
Schistosoma mansoni | apoptosis regulator bax | 0.145255 | 0.446445 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.00185195 | 0.00437598 | 0.00980183 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.00992293 | 0.0292563 | 0.0292563 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.145255 | 0.446445 | 0.446445 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.00272918 | 0.00708023 | 0.0158591 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.324824 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0523006 | 0.159894 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.00605319 | 0.0173271 | 0.108366 |
Brugia malayi | Matrixin family protein | 0.00272918 | 0.00708023 | 0.0158591 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0248809 | 0.0753672 | 0.440146 |
Loa Loa (eye worm) | hypothetical protein | 0.00272918 | 0.00708023 | 0.0158591 |
Loa Loa (eye worm) | matrixin family protein | 0.00659892 | 0.0190095 | 0.0425796 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.00696311 | 0.0201322 | 0.0201322 |
Onchocerca volvulus | 0.00386974 | 0.0105962 | 0.0662703 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0523006 | 0.159894 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0248809 | 0.0753672 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.00386974 | 0.0105962 | 0.0237346 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.145255 | 0.446445 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0523006 | 0.159894 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antiplasmodial activity against erythrocytic stage of multidrug-resistant Plasmodium falciparum Thailand K1 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 24900723 | |
IC50 (functional) | = 0.22 uM | Antiplasmodial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum IndoChina W2 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 24900723 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 24900723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.