TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 571.687 | Formula: C32H33N3O5S
H donors: 0 H acceptors: 2 LogP: 5.02 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CN(CCN(C(=O)COc1ccc(c2c1c1ccccc1s2)c1cccc2c1oc(cc2=O)N1CCOCC1)C)C
InChi: 1S/C32H33N3O5S/c1-33(2)13-14-34(3)28(37)20-39-26-12-11-22(32-30(26)24-7-4-5-10-27(24)41-32)21-8-6-9-23-25(36)19-29(40-31(21)23)35-15-17-38-18-16-35/h4-12,19H,13-18,20H2,1-3H3
InChiKey: FCMSNWCBNHSTMY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Onchocerca volvulus		0.0273	0.8629	0.5
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0273	0.8629	0.8629
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0273	0.8629	0.8629
Onchocerca volvulus		0.0273	0.8629	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	serotonin receptor	0.0273	0.8629	0.8629
Brugia malayi	Melatonin receptor type 1A	0.0273	0.8629	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0273	0.8629	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0273	0.8629	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0273	0.8629	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0273	0.8629	1
Loa Loa (eye worm)	TYRA-2 protein	0.0273	0.8629	1
Giardia lamblia	GTOR	0.0022	0	0.5
Brugia malayi	Dopamine receptor	0.0273	0.8629	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	fmrfamide receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0273	0.8629	0.5
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0273	0.8629	0.8629
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0273	0.8629	0.8629
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Echinococcus granulosus	neuropeptide s receptor	0.0273	0.8629	0.8629
Echinococcus granulosus	neuropeptide Y receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	g protein coupled receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	neuropeptide receptor A26	0.0273	0.8629	0.8629
Onchocerca volvulus		0.0273	0.8629	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	neuropeptide receptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Echinococcus multilocularis	somatostatin receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	sex peptide receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0273	0.8629	0.8629
Echinococcus granulosus	biogenic amine 5HT receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0273	0.8629	0.8629
Echinococcus granulosus	g-protein coupled receptor	0.0273	0.8629	0.8629
Echinococcus granulosus	neuropeptide receptor A26	0.0273	0.8629	0.8629
Brugia malayi	putative neuropeptide receptor	0.0273	0.8629	1
Brugia malayi	ORL1-like opioid receptor	0.0273	0.8629	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0273	0.8629	0.8629
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0273	0.8629	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0273	0.8629	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0273	0.8629	0.8629
Onchocerca volvulus		0.0273	0.8629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	hypothetical protein	0.0273	0.8629	0.8629
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0273	0.8629	0.8629
Leishmania major	hypothetical protein, conserved	0.0114	0.3155	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0273	0.8629	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0273	0.8629	0.8629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Brugia malayi	sulfakinin receptor protein	0.0273	0.8629	1
Schistosoma mansoni	amine GPCR	0.0273	0.8629	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	amine GPCR	0.0273	0.8629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	biogenic amine receptor	0.0273	0.8629	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0273	0.8629	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0273	0.8629	0.8629
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0273	0.8629	1
Brugia malayi	Dopamine receptor protein 1	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Echinococcus multilocularis	G protein coupled receptor 139	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0273	0.8629	0.8629
Loa Loa (eye worm)	neuropeptide F receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	g protein coupled receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	serotonin receptor	0.0273	0.8629	0.8629
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0	0.5
Schistosoma mansoni	histamine h1 receptor	0.0273	0.8629	1
Brugia malayi	larval opioid receptor	0.0273	0.8629	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Schistosoma mansoni	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0	0.5
Brugia malayi	G protein-coupled receptor	0.0273	0.8629	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0273	0.8629	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0273	0.8629	0.8629
Echinococcus granulosus	somatostatin receptor	0.0273	0.8629	0.8629
Onchocerca volvulus		0.0273	0.8629	0.5
Brugia malayi	neuropeptide F receptor	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	neuropeptide receptor	0.0273	0.8629	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Brugia malayi	Serotonin receptor	0.0273	0.8629	1
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3011	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0273	0.8629	1
Schistosoma mansoni	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Echinococcus multilocularis	g protein coupled receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	G-protein coupled receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	neuropeptide receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Onchocerca volvulus		0.0273	0.8629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0273	0.8629	1
Schistosoma mansoni	myosin xvIII	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	biogenic amine receptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0273	0.8629	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0273	0.8629	0.8629
Echinococcus granulosus	neuropeptides capa receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	adenoreceptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0273	0.8629	0.8629
Brugia malayi	follicle stimulating hormone receptor	0.0273	0.8629	1
Echinococcus multilocularis	orexin receptor type 2	0.0273	0.8629	0.8629
Echinococcus granulosus	g protein coupled receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	neuropeptide F receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0273	0.8629	1
Schistosoma mansoni	amine GPCR	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0273	0.8629	1
Schistosoma mansoni	biogenic amine receptor	0.0273	0.8629	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0273	0.8629	0.8629
Brugia malayi	AKH receptor	0.0273	0.8629	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0273	0.8629	0.8629
Echinococcus granulosus	orexin receptor type 2	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0273	0.8629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Brugia malayi	Serotonin receptor	0.0273	0.8629	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0273	0.8629	1
Echinococcus multilocularis	allatostatin A receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	G-protein coupled receptor	0.0273	0.8629	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	opsin-like receptor	0.0273	0.8629	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0273	0.8629	1
Schistosoma mansoni	opsin-like receptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Brugia malayi	Dopamine receptor protein 2	0.0273	0.8629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Echinococcus multilocularis	neuropeptide receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Echinococcus granulosus	neuropeptide receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	neuropeptide Y receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	neuropeptide receptor	0.0273	0.8629	0.8629
Onchocerca volvulus		0.0273	0.8629	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0273	0.8629	0.8629
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0	0.5
Schistosoma mansoni	amine GPCR	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0273	0.8629	0.8629
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	sex peptide receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Schistosoma mansoni	amine GPCR	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	neuropeptide s receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0273	0.8629	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0	0.5
Onchocerca volvulus		0.0273	0.8629	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	RE15519p	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Echinococcus granulosus	neuropeptides capa receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	G-protein coupled receptor	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Onchocerca volvulus		0.0273	0.8629	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0273	0.8629	0.8629
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0273	0.8629	0.8629
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Schistosoma mansoni	opsin-like receptor	0.0273	0.8629	1
Brugia malayi	neuropeptide F receptor	0.0273	0.8629	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.8629	1
Brugia malayi	hypothetical protein	0.0273	0.8629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Echinococcus granulosus	7TM GPCR rhodopsin	0.0273	0.8629	0.8629
Echinococcus multilocularis	fmrfamide receptor	0.0273	0.8629	0.8629
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0	0.5
Brugia malayi	GnHR receptor homolog	0.0273	0.8629	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0273	0.8629	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0273	0.8629	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0273	0.8629	1
Onchocerca volvulus		0.0273	0.8629	0.5
Schistosoma mansoni	neuropeptide receptor	0.0273	0.8629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	fmrfamide receptor	0.0273	0.8629	0.8629
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0273	0.8629	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0273	0.8629	1
Echinococcus granulosus	allatostatin A receptor	0.0273	0.8629	0.8629
Echinococcus granulosus	neuropeptide Y receptor	0.0273	0.8629	0.8629
Schistosoma mansoni	neuropeptide receptor	0.0273	0.8629	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0273	0.8629	0.8629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0273	0.8629	0.8629
Brugia malayi	hypothetical protein	0.0273	0.8629	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 53 nM	Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assay	ChEMBL.	23855836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2420259

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1771500