TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 597.724 | Formula: C34H35N3O5S
H donors: 0 H acceptors: 2 LogP: 5.6 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCN(CC1)C(C)C)COc1ccc(c2c1c1ccccc1s2)c1cccc2c1oc(cc2=O)N1CCOCC1
InChi: 1S/C34H35N3O5S/c1-22(2)35-12-14-36(15-13-35)30(39)21-41-28-11-10-24(34-32(28)26-6-3-4-9-29(26)43-34)23-7-5-8-25-27(38)20-31(42-33(23)25)37-16-18-40-19-17-37/h3-11,20,22H,12-19,21H2,1-2H3
InChiKey: WAQBFBZSBDGNGY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0027	0.02	0.2203
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0047	0.0909	0.0909
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.02	0.02
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0037	0.0411
Echinococcus multilocularis	SH2 motif	0.0027	0.02	0.02
Brugia malayi	protein-tyrosine kinase	0.0047	0.0909	1
Schistosoma mansoni	tyrosine kinase	0.0047	0.0909	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Onchocerca volvulus		0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0027	0.02	0.2203
Onchocerca volvulus		0.0027	0.02	0.2203
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Echinococcus granulosus	SHC transforming protein 3	0.0027	0.02	0.02
Onchocerca volvulus		0.0047	0.0909	1
Echinococcus granulosus	SH2 motif	0.0027	0.02	0.02
Brugia malayi	SH2 domain containing protein	0.0047	0.0909	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.02	0.02
Schistosoma mansoni	signal transduction protein lnk-related	0.0027	0.02	0.2203
Echinococcus granulosus	signal transduction protein lnk realted	0.0027	0.02	0.02
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0027	0.02	0.2203
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Echinococcus granulosus	tyrosine kinase	0.0047	0.0909	0.0909
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0037	0.0037
Echinococcus granulosus	tyrosine kinase	0.0047	0.0909	0.0909
Echinococcus multilocularis	SH2 domain containing protein 7	0.0027	0.02	0.02
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Loa Loa (eye worm)	TK protein kinase	0.0047	0.0909	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Echinococcus multilocularis	tensin	0.0027	0.02	0.02
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0037	0.0411
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Brugia malayi	SRC-1	0.0047	0.0909	1
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0037	1
Entamoeba histolytica	SH2 domain containing protein	0.0027	0.02	0.2203
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0047	0.0909	0.0909
Echinococcus multilocularis	signal transduction protein lnk realted	0.0027	0.02	0.02
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0027	0.02	0.2203
Onchocerca volvulus		0.0027	0.02	0.2203
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0027	0.02	0.02
Echinococcus granulosus	growth factor receptor bound protein 2	0.0027	0.02	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Schistosoma mansoni	tyrosine kinase	0.0047	0.0909	1
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0909	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0037	0.0411
Echinococcus multilocularis	N chimaerin	0.0027	0.02	0.02
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0027	0.02	0.02
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0037	0.0411
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0047	0.0909	0.0909
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0047	0.0909	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0037	0.0123
Schistosoma mansoni	SH2A	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0047	0.0909	0.0909
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0047	0.0909	0.0909
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0047	0.0909	0.0909
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0027	0.02	0.2203
Onchocerca volvulus		0.0047	0.0909	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0027	0.02	0.2203
Schistosoma mansoni	hypothetical protein	0.0027	0.02	0.2203
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0027	0.02	0.02
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0047	0.0909	0.0909
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0047	0.0909	0.0909
Entamoeba histolytica	protein kinase, putative	0.0027	0.02	0.2203
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0027	0.02	0.2203
Schistosoma mansoni	tyrosine kinase	0.0047	0.0909	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0037	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0909	1
Echinococcus multilocularis	NCK adaptor protein	0.0027	0.02	0.02
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.02	0.02
Brugia malayi	hypothetical protein	0.0047	0.0909	1
Echinococcus granulosus	hypothetical protein	0.0027	0.02	0.02
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0	0.5
Schistosoma mansoni	tensin	0.0027	0.02	0.2203
Loa Loa (eye worm)	SH2 domain-containing protein	0.0027	0.02	0.2203
Onchocerca volvulus		0.0027	0.02	0.2203
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0037	0.0411
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0047	0.0909	0.0909
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0909	1
Echinococcus granulosus	NCK adaptor protein	0.0027	0.02	0.02
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.02	0.2203
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0037	0.0037
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0027	0.02	0.02
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0027	0.02	0.2203
Echinococcus multilocularis		0.0027	0.02	0.02
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0037	0.0123
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0047	0.0909	0.0909
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0027	0.02	0.2203
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0027	0.02	0.02
Schistosoma mansoni	growth factor receptor-bound protein	0.0027	0.02	0.2203
Echinococcus granulosus	c src tyrosine kinase	0.0047	0.0909	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0027	0.02	0.02
Echinococcus multilocularis	SHC transforming protein 3	0.0027	0.02	0.02
Leishmania major	hypothetical protein, conserved	0.0114	0.318	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0027	0.02	0.02
Schistosoma mansoni	nck2/grb4	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0047	0.0909	0.0909
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0027	0.02	0.02
Plasmodium falciparum	protein kinase, putative	0.0021	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Schistosoma mansoni	vav2	0.0027	0.02	0.2203
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0027	0.02	0.02
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0047	0.0909	0.0909
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0037	0.0411
Schistosoma mansoni	tyrosine kinase	0.0047	0.0909	1
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.02	0.2203
Echinococcus granulosus	SH2 motif	0.0027	0.02	0.02
Brugia malayi	hypothetical protein	0.0027	0.02	0.2203
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.0123
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0037	1
Schistosoma mansoni	tyrosine kinase	0.0047	0.0909	1
Onchocerca volvulus		0.0047	0.0909	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0027	0.02	0.02
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0037	1
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3037	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Onchocerca volvulus		0.0047	0.0909	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0037	0.0411
Echinococcus multilocularis	c src tyrosine kinase	0.0047	0.0909	0.0909
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0047	0.0909	0.0909
Schistosoma mansoni	adapter molecule crk	0.0027	0.02	0.2203
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0037	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Onchocerca volvulus		0.0047	0.0909	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0027	0.02	0.2203
Echinococcus granulosus	expressed conserved protein	0.0027	0.02	0.02
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0027	0.02	0.02
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0047	0.0909	0.0909
Schistosoma mansoni	suppressor of cytokine signaling	0.0027	0.02	0.2203
Schistosoma mansoni	growth factor receptor-bound protein	0.0027	0.02	0.2203
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Schistosoma mansoni	GTPase activating protein	0.0027	0.02	0.2203
Schistosoma mansoni	tensin	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0047	0.0909	0.0909
Echinococcus multilocularis	SH2 motif	0.0027	0.02	0.02
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0037	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0027	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Brugia malayi	Tensin	0.0027	0.02	0.2203
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0047	0.0909	0.0909
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Echinococcus granulosus	SH2 domain containing protein 7	0.0027	0.02	0.02
Plasmodium vivax	protein kinase, putative	0.0021	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0047	0.0909	0.0909
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0037	0.0123
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0027	0.02	0.02
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.0123
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0047	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0027	0.02	0.02
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0037	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.02	0.02
Plasmodium falciparum	protein kinase, putative	0.0021	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0909	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0909	1
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.02	0.2203
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0047	0.0909	1
Schistosoma mansoni	tensin-related	0.0027	0.02	0.2203
Echinococcus granulosus	N chimaerin	0.0027	0.02	0.02
Echinococcus granulosus	tensin	0.0027	0.02	0.02
Schistosoma mansoni	suppressor of cytokine signaling	0.0027	0.02	0.2203
Loa Loa (eye worm)	SRC-1	0.0047	0.0909	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0047	0.0909	0.0909
Plasmodium falciparum	protein kinase, putative	0.0021	0	0.5
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	1
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0047	0.0909	0.0909
Echinococcus granulosus	tyrosine protein kinase Blk	0.0047	0.0909	0.0909
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0	0.5
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0027	0.02	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Onchocerca volvulus		0.0027	0.02	0.2203
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0037	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Schistosoma mansoni	tyrosine kinase	0.0047	0.0909	1
Brugia malayi	SH2 domain containing protein	0.0047	0.0909	1
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	STAT protein	0.0027	0.02	0.2203
Onchocerca volvulus		0.0027	0.02	0.2203
Schistosoma mansoni	tensin-related	0.0027	0.02	0.2203
Echinococcus multilocularis	SH2 motif	0.0027	0.02	0.02
Brugia malayi	Tyrosine-protein kinase abl-1	0.0047	0.0909	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.0909	0.0909
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0037	0.0118
Loa Loa (eye worm)	TK/ABL protein kinase	0.0047	0.0909	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0037	0.0118
Brugia malayi	SH2 domain containing protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0909	1
Echinococcus multilocularis	tensin	0.0027	0.02	0.02
Schistosoma mansoni	shc transforming protein	0.0027	0.02	0.2203
Echinococcus multilocularis	tyrosine kinase	0.0047	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Giardia lamblia	GTOR	0.0022	0.0037	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0047	0.0909	0.0909
Brugia malayi	RhoGAP domain containing protein	0.0027	0.02	0.2203
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0027	0.02	0.2203
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0037	0.0118
Echinococcus granulosus	tyrosine protein kinase shark	0.0047	0.0909	0.0909
Brugia malayi	Sex muscle abnormal protein 5	0.0027	0.02	0.2203
Loa Loa (eye worm)	TK/FER protein kinase	0.0047	0.0909	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0027	0.02	0.2203
Onchocerca volvulus		0.0047	0.0909	1
Schistosoma mansoni	tensin	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.02	0.2203
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0047	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0027	0.02	0.2203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0037	0.0411
Schistosoma mansoni	hypothetical protein	0.0027	0.02	0.2203

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 16 nM	Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assay	ChEMBL.	23855836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2420263

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1771504