Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | peptide deformylase | 0.0244 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0244 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0244 | 0.5 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0244 | 0.5 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0244 | 0.5 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0244 | 0.5 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0244 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0244 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 32 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by broth microdilution method | ChEMBL. | 23867166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.