Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1182 | 0.5 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.1182 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1182 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1182 | 0.5 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1182 | 0.5 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1182 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1182 | 0.5 | 0.5 | |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1182 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1182 | 0.5 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1182 | 0.5 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1182 | 0.5 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.1182 | 0.5 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1182 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1182 | 0.5 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1182 | 0.5 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1182 | 0.5 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1182 | 0.5 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.1182 | 0.5 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1182 | 0.5 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1182 | 0.5 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1182 | 0.5 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.1182 | 0.5 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1182 | 0.5 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1182 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.32 mM | In vitro inhibition of Thromboxane B2 (TXB2) production in glycogen-induced peritoneal cells of rat | ChEMBL. | 8759636 |
IC50 (functional) | = 4.4 mM | In vitro inhibition of Leukotriene B4 (LTB4) production in glycogen-induced peritoneal cells of rat | ChEMBL. | 8759636 |
IC50 (functional) | = 100 mM | Compound was evaluated in Vitro in glycogen induced peritoneal cells of rats(GPEC) for the inhibition of Prostaglandin E2 (PGE2) production at 0.1-1 microM | ChEMBL. | 8759636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.