Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 31.8 % | Induction of apoptosis in human PC3 cells assessed as apoptotic rate at 10 uM after 72 hrs by annexin-V FITC and propidium iodide staining-based FACS flow cytometric analysis relative to control | ChEMBL. | 23811258 |
IC50 (functional) | = 3.1 uM | Antiproliferative activity against human Bcap37 cells by MTT assay | ChEMBL. | 24583357 |
IC50 (functional) | = 6.2 uM | Growth inhibition of human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 23811258 |
Inhibition (functional) | = 90.4 % | Antiproliferative activity against human Bcap37 cells at 10 uM by MTT assay | ChEMBL. | 24583357 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23811258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.