Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0276 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0276 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0276 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0276 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0276 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0276 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 62.5 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 to 72 hrs by microdilution method | ChEMBL. | 23831810 |
MIC (functional) | > 125 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 after 24 to 72 hrs by microdilution method | ChEMBL. | 23831810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.