Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0651 | 0.3861 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0651 | 0.3861 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0651 | 0.3861 | 0.2431 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0651 | 0.3861 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0369 | 0.1888 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.153 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0651 | 0.3861 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0852 | 0.5262 | 0.4159 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.153 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.153 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0651 | 0.3861 | 0.2431 |
Schistosoma mansoni | serine/threonine protein kinase | 0.153 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0651 | 0.3861 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0651 | 0.3861 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0651 | 0.3861 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0651 | 0.3861 | 0.2431 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.153 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0369 | 0.1888 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0651 | 0.3861 | 0.2431 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0651 | 0.3861 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0651 | 0.3861 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.153 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0651 | 0.3861 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.153 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0651 | 0.3861 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation counting | ChEMBL. | 23845219 |
IC50 (binding) | = 3.7 uM | Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation counting | ChEMBL. | 23845219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.