TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.474 | Formula: C18H25N3O3S
H donors: 2 H acceptors: 4 LogP: 4.69 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCC(=O)Nc1nnc(s1)c1ccc(c(c1)OC)O
InChi: 1S/C18H25N3O3S/c1-3-4-5-6-7-8-9-16(23)19-18-21-20-17(25-18)13-10-11-14(22)15(12-13)24-2/h10-12,22H,3-9H2,1-2H3,(H,19,21,23)
InChiKey: VMUGFJHHAQTKCY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase ABL1	0.038	0.9988	0.9987
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0229	0.3852	0.3383
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0229	0.3852	0.3383
Schistosoma mansoni	tyrosine kinase	0.038	0.9988	0.9987
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Schistosoma mansoni	growth factor receptor-bound protein	0.0229	0.3852	0.3383
Echinococcus granulosus	hypothetical protein	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	tensin	0.0229	0.3852	0.3383
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0229	0.3852	0.3383
Schistosoma mansoni	nck2/grb4	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	expressed conserved protein	0.0229	0.3852	0.3383
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0229	0.3852	0.3387
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0229	0.3852	0.3387
Schistosoma mansoni	tyrosine kinase	0.038	0.9988	0.9987
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0229	0.3852	0.3383
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0229	0.3852	0.3387
Brugia malayi	hypothetical protein	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.038	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.038	0.9988	0.9987
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0229	0.3852	0.3383
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Onchocerca volvulus		0.0229	0.3852	0.3387
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.038	0.9988	0.9987
Loa Loa (eye worm)	SH2 domain-containing protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0151	0.0709	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0229	0.3852	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Trypanosoma cruzi	protein kinase, putative	0.0151	0.0709	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Onchocerca volvulus		0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	SH2 motif	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	hypothetical protein	0.038	0.9988	1
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Echinococcus granulosus	c src tyrosine kinase	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0229	0.3852	0.3383
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0229	0.3852	0.3383
Trichomonas vaginalis	TK family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0229	0.3852	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Echinococcus multilocularis	tyrosine protein kinase Blk	0.038	0.9988	0.9987
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Plasmodium falciparum	protein kinase, putative	0.0151	0.0709	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Schistosoma mansoni	shc transforming protein	0.0229	0.3852	0.3383
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.038	0.9988	0.9987
Schistosoma mansoni	SH2A	0.0229	0.3852	0.3383
Echinococcus granulosus	N chimaerin	0.0229	0.3852	0.3383
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.038	0.9988	0.9987
Schistosoma mansoni	tensin	0.0229	0.3852	0.3383
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0229	0.3852	0.3387
Echinococcus granulosus	tyrosine kinase	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	protein kinase	0.0152	0.0721	0.0013
Onchocerca volvulus		0.038	0.9988	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	tyrosine kinase	0.038	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.038	0.9988	0.9987
Loa Loa (eye worm)	SH2 domain-containing protein	0.0229	0.3852	0.3387
Echinococcus multilocularis	NCK adaptor protein	0.0229	0.3852	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0229	0.3852	0.3383
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0229	0.3852	0.3383
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0151	0.0709	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0229	0.3852	0.3383
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0229	0.3852	0.3383
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Echinococcus multilocularis	SH2 motif	0.0229	0.3852	0.3383
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.038	0.9988	0.9987
Brugia malayi	protein-tyrosine kinase	0.038	0.9988	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0151	0.0709	0.5
Brugia malayi	hypothetical protein	0.0229	0.3852	0.3387
Echinococcus multilocularis	SH2 motif	0.0229	0.3852	0.3383
Schistosoma mansoni	adapter molecule crk	0.0229	0.3852	0.3383
Echinococcus multilocularis	tensin	0.0229	0.3852	0.3383
Echinococcus granulosus	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.038	0.9988	0.9987
Trypanosoma brucei	protein kinase, putative	0.0151	0.0709	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0229	0.3852	0.3383
Schistosoma mansoni	GTPase activating protein	0.0229	0.3852	0.3383
Schistosoma mansoni	protein kinase	0.0152	0.0721	0.0013
Echinococcus multilocularis	SH2 domain containing protein 7	0.0229	0.3852	0.3383
Echinococcus granulosus	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0229	0.3852	0.3387
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0229	0.3852	0.3383
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0151	0.0709	0.5
Leishmania major	hypothetical protein, conserved	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.038	0.9988	0.9987
Onchocerca volvulus		0.0229	0.3852	0.3387
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Toxoplasma gondii	protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0229	0.3852	0.3383
Onchocerca volvulus		0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	SH2 motif	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0229	0.3852	0.3383
Toxoplasma gondii	STE kinase	0.0151	0.0709	0.5
Brugia malayi	Protein kinase domain containing protein	0.038	0.9988	1
Trypanosoma brucei	Pseudokinase, putative	0.0151	0.0709	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.038	0.9988	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0229	0.3852	0.3383
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0229	0.3852	0.3387
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Plasmodium vivax	protein kinase, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	tyrosine kinase	0.038	0.9988	0.9987
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0229	0.3852	0.3383
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0229	0.3852	0.3383
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.038	0.9988	0.9987
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0151	0.0709	0.5
Onchocerca volvulus		0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	tyrosine kinase	0.038	0.9988	0.9987
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0229	0.3852	0.3383
Brugia malayi	SH2 domain containing protein	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	tyrosine kinase	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Onchocerca volvulus		0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.038	0.9988	0.9987
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0229	0.3852	0.3383
Brugia malayi	Variant SH3 domain containing protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0229	0.3852	0.3387
Onchocerca volvulus		0.0229	0.3852	0.3387
Echinococcus granulosus	tyrosine protein kinase Src42A	0.038	0.9988	0.9987
Echinococcus multilocularis		0.0229	0.3852	0.3383
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.038	0.9988	0.9987
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0151	0.0709	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Onchocerca volvulus		0.0229	0.3852	0.3387
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0229	0.3852	0.3383
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0151	0.0709	0.5
Plasmodium falciparum	protein kinase, putative	0.0151	0.0709	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0229	0.3852	0.3387
Schistosoma mansoni	hypothetical protein	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0134	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	tensin	0.0229	0.3852	0.3383
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.038	0.9988	0.9987
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0151	0.0709	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.038	0.9988	0.9987
Entamoeba histolytica	SH2 domain containing protein	0.0229	0.3852	0.3387
Brugia malayi	Variant SH3 domain containing protein	0.0229	0.3852	0.3387
Brugia malayi	Tensin	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Echinococcus granulosus	SH2 domain containing protein 7	0.0229	0.3852	0.3383
Onchocerca volvulus		0.038	0.9988	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0229	0.3852	0.3383
Schistosoma mansoni	signal transduction protein lnk-related	0.0229	0.3852	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Echinococcus granulosus	SH2 motif	0.0229	0.3852	0.3383
Brugia malayi	SRC-1	0.038	0.9988	1
Loa Loa (eye worm)	TK protein kinase	0.038	0.9988	1
Brugia malayi	Sex muscle abnormal protein 5	0.0229	0.3852	0.3387
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.038	0.9988	0.9987
Schistosoma mansoni	tyrosine kinase	0.038	0.9988	0.9987
Leishmania major	protein kinase, putative	0.0151	0.0709	0.5
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	SRC-1	0.038	0.9988	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.038	0.9988	0.9987
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0229	0.3852	0.3383
Toxoplasma gondii	protein kinase domain-containing protein	0.0151	0.0709	0.5
Entamoeba histolytica	protein kinase, putative	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.038	0.9988	0.9987
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trypanosoma cruzi	protein kinase, putative	0.0151	0.0709	0.5
Onchocerca volvulus		0.038	0.9988	1
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0229	0.3852	0.3387
Brugia malayi	Protein kinase domain containing protein	0.038	0.9988	1
Loa Loa (eye worm)	TK/FER protein kinase	0.038	0.9988	1
Schistosoma mansoni	tensin	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Trichomonas vaginalis	STE family protein kinase	0.0151	0.0709	0.5
Brugia malayi	Protein kinase domain containing protein	0.038	0.9988	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.038	0.9988	0.9987
Brugia malayi	SH2 domain containing protein	0.038	0.9988	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0229	0.3852	0.3387
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0151	0.0709	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.038	0.9988	0.9987
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Loa Loa (eye worm)	STAT protein	0.0229	0.3852	0.3387
Schistosoma mansoni	tensin-related	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Plasmodium falciparum	protein kinase, putative	0.0151	0.0709	0.5
Schistosoma mansoni	vav2	0.0229	0.3852	0.3383
Echinococcus granulosus	growth factor receptor bound protein 2	0.0229	0.3852	0.3383
Echinococcus granulosus	tyrosine protein kinase Src64B	0.038	0.9988	0.9987
Schistosoma mansoni	tensin	0.0229	0.3852	0.3383
Brugia malayi	RhoGAP domain containing protein	0.0229	0.3852	0.3387
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0151	0.0709	0.5
Brugia malayi	Protein kinase domain containing protein	0.038	0.9988	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.398	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Onchocerca volvulus		0.038	0.9988	1
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Schistosoma mansoni	tensin-related	0.0229	0.3852	0.3383
Echinococcus granulosus	tyrosine kinase	0.038	0.9988	0.9987
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0229	0.3852	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Loa Loa (eye worm)	TK/ABL protein kinase	0.038	0.9988	1
Brugia malayi	Variant SH3 domain containing protein	0.0229	0.3852	0.3387
Schistosoma mansoni	hypothetical protein	0.0229	0.3852	0.3383
Echinococcus granulosus	tyrosine protein kinase Lyn	0.038	0.9988	0.9987
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0151	0.0709	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Brugia malayi	SH2 domain containing protein	0.0229	0.3852	0.3387
Leishmania major	protein kinase, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0709	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0229	0.3852	0.3383
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Giardia lamblia	Kinase, NEK	0.0152	0.0721	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.0709	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0151	0.0709	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0151	0.0709	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0229	0.3852	0.3387
Echinococcus multilocularis	N chimaerin	0.0229	0.3852	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3852	0.3387
Echinococcus granulosus	NCK adaptor protein	0.0229	0.3852	0.3383
Brugia malayi	Protein kinase domain containing protein	0.038	0.9988	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.05 nM	Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo-4AM based fluorescence assay	ChEMBL.	23796768
IC50 (binding)	= 0.18 nM	Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4AM based fluorescence assay	ChEMBL.	23796768
Inhibition (binding)	= 79.38 %	Antagonist activity at chicken TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux at 1 uM after 30 mins by cell based Fluo-4AM fluorescence assay relative to control	ChEMBL.	23796768
Inhibition (binding)	= 92.92 %	Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux at 1 uM after 30 mins by Fluo-4AM based fluorescence assay relative to control	ChEMBL.	23796768
Inhibition (binding)	= 98.75 %	Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux at 1 uM after 30 mins by Fluo-4AM based fluorescence assay relative to control	ChEMBL.	23796768

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2414497

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1773117