Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Protein orai-1 | 0.4763 | 1 | 1 |
Echinococcus granulosus | calcium release activated calcium channel | 0.4763 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4763 | 1 | 1 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.4763 | 1 | 1 |
Schistosoma mansoni | Protein orai-1 | 0.4763 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 200 uM | Antiplasmodial activity against intraerythrocytic Plasmodium falciparum 3D7 infected in human erythrocytes in fresh RPMI-1640 culture medium assessed as parasite growth inhibition after 96 hrs by microscopic analysis in presence of pantetheinase | ChEMBL. | 24900746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.