Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 7 | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.125 | 0.1242 | 0.0908 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.125 | 0.1242 | 0.1057 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.125 | 0.1242 | 0.1057 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6605 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0677 | 0.0306 | 0.0306 |
Schistosoma mansoni | Protein orai-1 | 0.6605 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6605 | 1 | 1 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6605 | 1 | 1 |
Schistosoma mansoni | Protein orai-1 | 0.6605 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.125 | 0.1242 | 0.0908 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.0134 | 0.0134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1282 uM | Inhibition of alpha4beta1 integrin-mediated human jurkat cell adhesion to fibronectin in absence of human serum albumin | ChEMBL. | 23777782 |
IC50 (binding) | = 0.468 uM | Inhibition of alpha4beta7 integrin-mediated human 8866 cell adhesion to MadCAM-1 | ChEMBL. | 23777782 |
IC50 (binding) | = 61.6812 uM | Inhibition of alpha4beta1 integrin-mediated human jurkat cell adhesion to fibronectin in presence of human serum albumin | ChEMBL. | 23777782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.