Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nervana 2 | 0.0337 | 0.0033 | 0.8984 |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 1.2223 | 0.2417 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.034 | 0.0034 | 0.9195 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0355 | 0.0037 | 0.2698 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0512 | 0.0068 | 0.9589 |
Trypanosoma cruzi | Protein kinase B | 0.0355 | 0.0037 | 1 |
Echinococcus granulosus | nervana 2 | 0.0337 | 0.0033 | 0.8984 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0337 | 0.0033 | 0.8984 |
Entamoeba histolytica | protein kinase, putative | 0.0512 | 0.0068 | 0.9589 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0355 | 0.0037 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0337 | 0.0033 | 0.8984 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 5.0031 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0176 | 0.0001 | 0.0107 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0512 | 0.0068 | 0.9589 |
Trichomonas vaginalis | AGC family protein kinase | 0.0176 | 0.0001 | 0.0107 |
Echinococcus multilocularis | nervana 2 | 0.0337 | 0.0033 | 0.8984 |
Brugia malayi | Protein kinase domain containing protein | 0.0527 | 0.0071 | 1 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 1.2223 | 0.2417 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.019 | 0.0004 | 0.0514 |
Entamoeba histolytica | protein kinase 2, putative | 0.034 | 0.0034 | 0.4697 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0355 | 0.0037 | 0.5109 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0337 | 0.0033 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Leishmania major | methionine synthase, putative | 0.0727 | 0.0111 | 0.5 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 3.8535 | 0.7694 | 1 |
Toxoplasma gondii | dihydropteroate synthase | 1.2223 | 0.2417 | 1 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 1.2223 | 0.2417 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.034 | 0.0034 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0176 | 0.0001 | 0.0107 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.034 | 0.0034 | 0.9195 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0527 | 0.0071 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0355 | 0.0037 | 0.2698 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0527 | 0.0071 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.034 | 0.0034 | 0.9195 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0355 | 0.0037 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.084 | 0.0134 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0527 | 0.0071 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0355 | 0.0037 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0527 | 0.0071 | 1 |
Echinococcus granulosus | nervana 2 | 0.0337 | 0.0033 | 0.8984 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0355 | 0.0037 | 0.5109 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0527 | 0.0071 | 0.5 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0337 | 0.0033 | 0.8984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.