Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0142 | 0.0625 | 0.0589 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0363 | 0.4659 | 0.4638 |
Echinococcus multilocularis | pyruvate kinase | 0.0411 | 0.5531 | 0.7104 |
Echinococcus granulosus | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.052 | 0.7531 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.052 | 0.7531 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.052 | 0.7531 | 0.6672 |
Echinococcus multilocularis | pyruvate kinase | 0.052 | 0.7531 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.052 | 0.7531 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.052 | 0.7531 | 0.5 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0157 | 0.091 | 0.0876 |
Giardia lamblia | Pyruvate kinase | 0.052 | 0.7531 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.052 | 0.7531 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.052 | 0.7531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.052 | 0.7531 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.052 | 0.7531 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Mycobacterium ulcerans | pyruvate kinase | 0.052 | 0.7531 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.052 | 0.7531 | 0.7522 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0267 | 0.2911 | 0.3865 |
Echinococcus granulosus | pyruvate kinase | 0.052 | 0.7531 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.052 | 0.7531 | 0.7522 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0363 | 0.4659 | 0.5 |
Leishmania major | pyruvate kinase | 0.052 | 0.7531 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Echinococcus multilocularis | pyruvate kinase | 0.052 | 0.7531 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.052 | 0.7531 | 0.7522 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.7531 | 0.7522 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0249 | 0.2582 | 0.2834 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.052 | 0.7531 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0249 | 0.2582 | 0.2834 |
Loa Loa (eye worm) | pyruvate kinase | 0.052 | 0.7531 | 0.7522 |
Echinococcus granulosus | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0249 | 0.2582 | 0.2834 |
Trypanosoma brucei | pyruvate kinase 1 | 0.052 | 0.7531 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0249 | 0.2582 | 0.2554 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.4659 | 0.4638 |
Echinococcus multilocularis | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Leishmania major | pyruvate kinase | 0.052 | 0.7531 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.052 | 0.7531 | 0.7522 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.052 | 0.7531 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0656 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.052 | 0.7531 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.052 | 0.7531 | 0.6672 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.052 | 0.7531 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.052 | 0.7531 | 0.6672 |
Schistosoma mansoni | pyruvate kinase | 0.052 | 0.7531 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.052 | 0.7531 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0249 | 0.2582 | 0.2554 |
Echinococcus multilocularis | pyruvate kinase | 0.0267 | 0.2911 | 0.331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 100 uM | Binding affinity to catalytic domain of human PARP1 after 5 mins by surface plasmon resonance assay | ChEMBL. | 23850199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.