Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | pyruvate kinase 1 | 0.1772 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.1772 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.1772 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.1772 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.1399 | 0.6979 | 0.5671 |
Echinococcus multilocularis | pyruvate kinase | 0.1772 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.1772 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.1772 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.1772 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.1772 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.1772 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.1772 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.1772 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.1772 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.1772 | 1 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.1772 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.1772 | 1 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.1772 | 1 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.1772 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.1772 | 1 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.1772 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.1772 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1772 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.1236 | 0.5661 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.1772 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.1772 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.1772 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.1772 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.1772 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.1772 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.1772 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.1772 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.95 uM | Inhibition of GIRK1/2 (unknown origin) | ChEMBL. | 23838260 |
IC50 (binding) | > 30 uM | Inhibition of GIRK1/4 (unknown origin) | ChEMBL. | 23838260 |
Inhibition (binding) | = 86 % | Inhibition of GIRK1/2 (unknown origin) relative to SCH3320 | ChEMBL. | 23838260 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.