Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.0337 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0337 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0309 | 0 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0337 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 85 % | Inhibition of human recombinant His-tagged SIRT3 using KI179 as substrate at 50 uM preincubated for 5 mins followed by enzyme addition measured after 1 hr by fluorescence assay relative to control | ChEMBL. | 23927550 |
Inhibition (binding) | = 86 % | Inhibition of human recombinant GST-tagged SIRT2 using KI179 as substrate at 50 uM preincubated for 5 mins followed by enzyme addition measured after 1 hr by fluorescence assay relative to control | ChEMBL. | 23927550 |
Inhibition (binding) | = 96 % | Inhibition of human recombinant GST-tagged SIRT1 using KI177 as substrate at 50 uM preincubated for 5 mins followed by enzyme addition measured after 1 hr by fluorescence assay relative to control | ChEMBL. | 23927550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.