Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Sigma opioid receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.6 nM | Displacement of [3H](+)-pentazocine from sigma 1 receptor in rat brain homogenates after 120 mins by liquid scintillation counting | ChEMBL. | 23896610 |
Ki (binding) | = 2300 nM | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 120 mins by liquid scintillation counting | ChEMBL. | 23896610 |
Ki (binding) | > 10000 nM | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 120 mins by liquid scintillation counting | ChEMBL. | 23896610 |
Ki (binding) | > 10000 nM | Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells after 120 mins by liquid scintillation counting | ChEMBL. | 23896610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.