Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase II | 0.2844 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2844 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2844 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1387 | 0.2209 | 0.1444 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2844 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1468 | 0.2639 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.2844 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1387 | 0.2209 | 0.1444 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2844 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1387 | 0.2209 | 0.1444 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1387 | 0.2209 | 0.1444 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2844 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1387 | 0.2209 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.2844 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1387 | 0.2209 | 0.1444 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1468 | 0.2639 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2844 | 1 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1141 | 0.0894 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2844 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1468 | 0.2639 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1141 | 0.0894 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1387 | 0.2209 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2844 | 1 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0974 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
INH (ADMET) | = 1.7 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 23601710 |
INH (ADMET) | > 30 uM | Inhibition of CYP2D6 (unknown origin) | ChEMBL. | 23601710 |
permeability (ADMET) | = 4.3 ucm/s | Permeability across human Caco2 cells | ChEMBL. | 23601710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.