Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0157 | 0.0035 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0157 | 0.0035 | 0.5 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.3784 | 0.2498 | 0.2472 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 1.483 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.3205 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1297 | 0.0808 | 0.0776 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0157 | 0.0035 | 0.0093 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0157 | 0.0035 | 0.0023 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.0776 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.3784 | 0.2498 | 0.2472 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.3784 | 0.2498 | 0.2472 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0157 | 0.0035 | 0.0023 |
Onchocerca volvulus | 0.3784 | 0.2498 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0035 | 0.0093 |
Echinococcus multilocularis | solute carrier family 5 | 1.483 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.0776 |
Schistosoma mansoni | sodium/solute symporter | 0.3784 | 0.2498 | 0.2489 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0157 | 0.0035 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.3205 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1297 | 0.0808 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0157 | 0.0035 | 0.0023 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1297 | 0.0808 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1297 | 0.0808 | 0.5 |
Onchocerca volvulus | 0.0123 | 0.0012 | 0.0046 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.0776 |
Brugia malayi | GH02984p | 0.3784 | 0.2498 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3784 | 0.2498 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.0776 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.3784 | 0.2498 | 0.2472 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0157 | 0.0035 | 0.5 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0157 | 0.0035 | 0.0093 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0157 | 0.0035 | 0.0093 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1297 | 0.0808 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3784 | 0.2498 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.3784 | 0.2498 | 0.2489 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 1.483 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.0776 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1297 | 0.0808 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1297 | 0.0808 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 1.483 | 1 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0157 | 0.0035 | 0.5 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0157 | 0.0035 | 0.0093 |
Echinococcus granulosus | solute carrier family 5 | 1.483 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.3205 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.3784 | 0.2498 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.3784 | 0.2498 | 1 |
Schistosoma mansoni | inositol transporter | 1.483 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1297 | 0.0808 | 0.5 |
Schistosoma mansoni | inositol transporter | 1.483 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0157 | 0.0035 | 0.0093 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1297 | 0.0808 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1297 | 0.0808 | 0.0798 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 1.483 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0157 | 0.0035 | 0.0093 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.017 uM | Inhibitory activity against trypsin | ChEMBL. | 8426361 |
IC50 (binding) | = 0.089 uM | Inhibitory activity against thrombin | ChEMBL. | 8426361 |
IC50 (binding) | = 0.094 uM | Inhibitory activity against plasmin | ChEMBL. | 8426361 |
IC50 (binding) | = 0.2 uM | Inhibitory activity against factor Xa | ChEMBL. | 8426361 |
IC50 (binding) | = 16 uM | Compound was tested in vitro for inhibitory activity against t-PA (tissue plasminogen activator) | ChEMBL. | 8426361 |
Selectivity ratio (binding) | = 1 | Selectivity was expressed as the ratio is IC 50 of plasmin / thrombin | ChEMBL. | 8426361 |
Selectivity ratio (binding) | = 180 | Selectivity was expressed as the ratio is IC 50 of t-PA / thrombin | ChEMBL. | 8426361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.