Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipocalin/cytosolic fatty-acid binding protein family protein | 0.76 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in NMRI mouse assessed as protection against subcutaneous pentylene tetrazole-induced seizure at 20 to 100 mg/kg, ip after 4 hrs | ChEMBL. | 23623419 | |
Activity (ADMET) | Neurotoxicity in NMRI mouse assessed as minimal motor impairment at 20 to 100 mg/kg, ip after 4 hrs by rotarod test | ChEMBL. | 23623419 | |
Activity (functional) | Anticonvulsant activity in NMRI mouse assessed as protection against maximal electroshock-induced seizures at 20 to 100 mg/kg, ip after 4 hrs | ChEMBL. | 23623419 | |
Activity (ADMET) | Neurotoxicity in NMRI mouse assessed as minimal motor impairment at 20 to 100 mg/kg, ip after 0.5 hrs by rotarod test | ChEMBL. | 23623419 | |
Activity (functional) | Anticonvulsant activity in NMRI mouse assessed as protection against maximal electroshock-induced seizures at 20 to 100 mg/kg, ip after 0.5 hrs | ChEMBL. | 23623419 | |
Activity (functional) | Anticonvulsant activity in NMRI mouse assessed as protection against subcutaneous pentylene tetrazole-induced seizure at 20 to 100 mg/kg, ip after 0.5 hrs | ChEMBL. | 23623419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.