Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.108 | 0 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.4233 | 1 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.108 | 0 | 0.5 |
Brugia malayi | Sodium:solute symporter family protein | 0.108 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.108 | 0 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.4233 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.4233 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.4233 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.4233 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.4233 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.4233 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.4233 | 1 | 1 |
Brugia malayi | GH02984p | 0.108 | 0 | 0.5 |
Onchocerca volvulus | 0.108 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assay; ND means not determined | ChEMBL. | 10576684 |
IC50 (binding) | 0 uM | In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assay; ND means not determined | ChEMBL. | 10576684 |
IC50 (binding) | = 0.02 uM | In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells | ChEMBL. | 10576684 |
IC50 (binding) | = 0.02 uM | In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells | ChEMBL. | 10576684 |
IC50 (binding) | = 0.04 uM | In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assay | ChEMBL. | 10576684 |
IC50 (binding) | = 0.04 uM | In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assay | ChEMBL. | 10576684 |
IC50 (binding) | < 0.3 uM | In vitro inhibitory potency against U-937 microsomal COX-1 | ChEMBL. | 10576684 |
IC50 (binding) | < 0.3 uM | In vitro inhibitory potency against U-937 microsomal COX-1 | ChEMBL. | 10576684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.