TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 700.672 | Formula: C32H38F6N6O5
H donors: 7 H acceptors: 5 LogP: 6.14 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.Nc1ccc2c(c1)c1NCCCCCNc3cc[n+](CCCCC[n+]2cc1)c1ccc(cc31)N.O
InChi: 1S/C28H34N6.2C2HF3O2.H2O/c29-21-7-9-27-23(19-21)25-11-17-33(27)15-5-2-6-16-34-18-12-26(32-14-4-1-3-13-31-25)24-20-22(30)8-10-28(24)34;2*3-2(4,5)1(6)7;/h7-12,17-20H,1-6,13-16,29-30H2;2*(H,6,7);1H2/b31-25+,32-26+;;;
InChiKey: BBPXQQWKXDAMSO-DHWQIPLESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Small conductance calcium-activated potassium channel protein 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01047 phospholipase A2 [EC3.1.1.4], putative	Get druggable targets OG5_130097	All targets in OG5_130097
Echinococcus multilocularis	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	calcium-activated potassium channel	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Echinococcus granulosus	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	IPR011996,SK channel region,domain-containing	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	neuropeptide F receptor	0.0174	0.3625	0.638
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus granulosus	serotonin receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	neuropeptide receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	biogenic amine receptor	0.0174	0.3625	0.7606
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Onchocerca volvulus		0.0174	0.3625	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus multilocularis	serotonin receptor	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0174	0.3625	0.7606
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0174	0.3625	0.7606
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Echinococcus multilocularis	fmrfamide receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	g protein coupled receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Schistosoma mansoni	opsin-like receptor	0.0174	0.3625	0.7606
Echinococcus granulosus	dro:myosuppressin receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	melatonin receptor type 1A	0.0174	0.3625	0.638
Echinococcus multilocularis	sex peptide receptor	0.0174	0.3625	0.3625
Brugia malayi	hypothetical protein	0.0237	0.5623	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0216	0.0201
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0174	0.3625	0.3625
Schistosoma mansoni	amine GPCR	0.0174	0.3625	0.7606
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	amine GPCR	0.0174	0.3625	0.7606
Loa Loa (eye worm)	G-protein coupled receptor	0.0174	0.3625	0.638
Echinococcus granulosus	somatostatin receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0237	0.5623	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus granulosus	orexin receptor type 2	0.0174	0.3625	0.3625
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	G-protein coupled receptor	0.0174	0.3625	0.638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	somatostatin receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0174	0.3625	0.638
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0174	0.3625	0.3625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Echinococcus granulosus	g protein coupled receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	TYRA-2 protein	0.0174	0.3625	0.638
Echinococcus granulosus	hypothetical protein	0.0174	0.3625	0.3625
Echinococcus multilocularis	neuropeptides capa receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus granulosus	neuropeptide receptor	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Schistosoma mansoni	amine GPCR	0.0174	0.3625	0.7606
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	amine GPCR	0.0174	0.3625	0.7606
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0174	0.3625	0.3625
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.5623	0.5623
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	neuropeptide Y receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	orexin receptor type 2	0.0174	0.3625	0.3625
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0174	0.3625	0.3625
Echinococcus granulosus	neuropeptide FF receptor 2	0.0174	0.3625	0.3625
Echinococcus multilocularis	neuropeptide s receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0174	0.3625	0.3625
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0174	0.3625	0.3625
Schistosoma mansoni	hypothetical protein	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus granulosus	neuropeptide Y receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	neuropeptide Y receptor	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Schistosoma mansoni	neuropeptide receptor	0.0174	0.3625	0.7606
Schistosoma mansoni	neuropeptide f receptor 76f	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0339	0.0424
Schistosoma mansoni	hypothetical protein	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	calcium-activated potassium channel	0.0136	0.2386	0.5007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus granulosus	7tm_1 domain containing protein	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Onchocerca volvulus		0.0174	0.3625	0.5
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus granulosus	small conductance calcium activated potassium	0.021	0.4767	0.4767
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0	0.5
Onchocerca volvulus		0.0174	0.3625	0.5
Schistosoma mansoni	biogenic amine receptor	0.0174	0.3625	0.7606
Echinococcus granulosus	g protein coupled receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	neuropeptides capa receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	neuropeptide F receptor	0.0174	0.3625	0.638
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	g protein coupled receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Onchocerca volvulus		0.0174	0.3625	0.5
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	small conductance calcium activated potassium	0.021	0.4767	0.4767
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	g-protein coupled receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	neuropeptide receptor	0.0174	0.3625	0.7606
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus granulosus	sex peptide receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	amine GPCR	0.0174	0.3625	0.7606
Echinococcus granulosus	fmrfamide receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	opsin-like receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	neuropeptide receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	neuropeptide receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0174	0.3625	0.638
Echinococcus granulosus	tm gpcr rhodopsin	0.0174	0.3625	0.3625
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0174	0.3625	0.3625
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	adenoreceptor	0.0174	0.3625	0.7606
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	g protein coupled receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Schistosoma mansoni	neuropeptide F-like receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0	0.5
Schistosoma mansoni	hypothetical protein	0.0174	0.3625	0.7606
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Schistosoma mansoni	hypothetical protein	0.0174	0.3625	0.7606
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0174	0.3625	0.7606
Schistosoma mansoni	myosin xvIII	0.0174	0.3625	0.7606
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0174	0.3625	0.3625
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0174	0.3625	0.5
Echinococcus granulosus	g protein coupled receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	neuropeptides capa receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	neuropeptide receptor A26	0.0174	0.3625	0.3625
Schistosoma mansoni	opsin-like receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0174	0.3625	0.3625
Echinococcus multilocularis	allatostatin A receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	neuropeptide Y receptor	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0174	0.3625	0.3625
Echinococcus multilocularis	fmrfamide receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	tm gpcr rhodopsin	0.0174	0.3625	0.3625
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0174	0.3625	0.3625
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	histamine h1 receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	dro:myosuppressin receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	7TM GPCR rhodopsin	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0174	0.3625	0.3625
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus granulosus	neuropeptide receptor A26	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	calcium-activated potassium channel	0.021	0.4767	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0174	0.3625	0.7606
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0174	0.3625	0.5
Echinococcus granulosus	allatostatin A receptor	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	hypothetical protein	0.021	0.4767	1
Echinococcus granulosus	neuropeptide s receptor	0.0174	0.3625	0.3625
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Echinococcus granulosus	biogenic amine 5HT receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.5623	0.5623
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0174	0.3625	0.638
Echinococcus multilocularis	expressed protein	0.0374	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0174	0.3625	0.7606
Echinococcus granulosus	rhodopsin orphan GPCR	0.0174	0.3625	0.3625
Onchocerca volvulus		0.0174	0.3625	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0174	0.3625	0.7606
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0174	0.3625	0.7606
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0174	0.3625	0.7606
Echinococcus granulosus	G protein coupled receptor 139	0.0174	0.3625	0.3625
Schistosoma mansoni	neuropeptide receptor	0.0174	0.3625	0.7606
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0174	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.021	0.4767	0.8448
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0174	0.3625	0.7606
Echinococcus granulosus	tm gpcr rhodopsin	0.0174	0.3625	0.3625
Echinococcus granulosus	g-protein coupled receptor	0.0174	0.3625	0.3625
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0174	0.3625	0.3625
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0174	0.3625	0.7606
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0174	0.3625	0.638
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3625	0.638
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0174	0.3625	0.3625
Echinococcus multilocularis	G protein coupled receptor 139	0.0174	0.3625	0.3625
Schistosoma mansoni	biogenic amine receptor	0.0174	0.3625	0.7606
Echinococcus multilocularis	serotonin receptor	0.0174	0.3625	0.3625

Activities

Activity type	Activity value	Assay description	Source	Reference
EMR (binding)	= 1.04	Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay relative to UCL1848	ChEMBL.	23685886
IC50 (binding)	= 2.3 nM	Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay	ChEMBL.	23685886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391665

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1777937